Sydney faces a tough night at selection with veteran star Luke Parker demanding to return to the senior team.
Collingwood will lose up to four forwards because of injury and suspension, while Brisbane also has worries with player availability.
The Sporting News has all the latest AFL team selection news.
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Carlton vs. Melbourne teams
After a disappointing loss to Collingwood, Carlton coach Michael Voss could shake up the team by dropping Zac Williams.
The big-money recruit has a glute injury and his poor form might see him axed, with Brodie Kemp or Jack Carroll possible replacements.
Orazio Fantasia has maintained his spot in the team despite little impact and patience could run out at selection this week.
Carlton will be hoping Mitch McGovern and Jack Martin return from injury but both could come back through the VFL.
Melbourne have announced Jake Bowey (collarbone) will come back in for his first match since Opening Round.
Daniel Turner could be the unlucky omission following a quiet game.
The Demons are unlikely to make many changes after a good win but Adam Tomlinson continues to perform strongly in the VFL.
Harrison Petty had been under pressure to perform and had his best game of the season vs. Geelong with nine marks and a goal.
Geelong vs. Port Adelaide teams
The Cats still have the shortest injury list of any AFL club with Patrick Dangerfield the only significant player not playing.
Midfield gun Tanner Bruhn (shoulder) will need to pass a fitness test after being subbed out against Melbourne.
A defeat vs. the Demons could see Chris Scott bring back managed players Brandan Parfitt and Mark O'Connor.
Solid VFL form will see Shaun Mannagh, Oisin Mullin and Toby Conway will come under consideration for selection.
Injuries will see plenty of movement at Port Adelaide selection after their Showdown loss to Adelaide.
Connor Rozee (hamstring) and Lachie Jones (hamstring) will come out, while Charlie Dixon (leg) and Mitch Georgiades (knee) are in doubt.
Expect Jeremy Finlayson to return after starring in the SANFL with four goals, following his return from suspension.
Midfielder Josh Sinn could also be considered after performing strongly in the midfield for the twos.
Fremantle vs. Sydney teams
It's unlikely Fremantle will make too many changes after a comprehensive win against Richmond.
Sam Darcy (calf tightness) should be right to play, but the axe could fall on debutant Cooper Simpson, who didn't have much impact.
Will Brodie has been dominating in the WAFL and is yet to crack a senior game this season.
Sydney are another team coming off a good win against GWS, but surely Luke Parker comes back in after another huge VFL performance.
Harry Cunningham or Sam Wicks would be the likely omissions for Parker after quiet games versus the Giants.
Hawthorn vs. St Kilda teams
After a stirring win against the Bulldogs, Hawthorn will be boosted by the return of Luke Breust.
Nick Watson or Cam McKenzie could come out with Sam Mitchell likely to stick fat with most of his winners.
Liam Henry (hamstring) will return for St Kilda in his first game since Round 2 against Collingwood.
Mattaes Phillipou continues to be anonymous in senior matches, while recent draftees Angus Hastie and Hugo Garcia could also return to the VFL to build form.
Zak Jones and Paddy Dow have also been impressive VFL performers over the last fortnight.
Essendon vs. GWS Giants teams
The Bombers may look to make a couple of changes after narrowly getting over line against West Coast.
Alwyn Davey Jnr has struggled for impact in recent weeks and could find himself out.
Sam Draper should return after being managed for a week, while Elijah Tsatas and Will Setterfield are closing in on senior action.
Question marks surround the fitness of GWS' Brownlow fancy Tom Green (ankle), who will need to pass a fitness test.
Callum Brown has also been suspended for three weeks for rough conduct.
Stephen Coniglio (knee) is expected to return, while Conor Stone and Nick Haynes will be first in line to come in from VFL performances
Richmond vs. Western Bulldogs teams
The Tigers could finally see an influx of injured players return including Dion Prestia (hamstring), Noah Balta (knee) and Jack Graham (hamstring).
All three do have to pass fitness tests, however.
Several Richmond players will come in contention for the axe including Kamdyn McIntosh, Maurice Rioli and Sam Banks.
It will be interesting to see Luke Beveridge's selection plans after the Bulldogs went down limply to Hawthorn.
Tom Liberatore is out suspended and through concussion protocols with one of Caleb Daniel or Ryley Sanders a lock to replace him.
Daniel and Sanders were both among the best at VFL level and could both come into the senior team.
Rhylee West will also be available after serving a suspension.
Potential omissions include Taylor Duryea, Charlie Charke and Harvey Gallagher.
Gold Coast vs. North Melbourne teams
Damien Hardwick is likely to make a statement at selection after a limp effort in the Q-clash.
Gold Coast players under threat include Ben Long, Ethan Read and Jake Rogers.
The Suns enjoyed a huge win in the VFL with several players impressing.
Jy Farrar and Sam Day kicked nine goals between each other, while Alex Sexton and Alex Davies found plenty of the ball.
The revolving selection door at North Melbourne will continue with the likes of Will Phillips, Charlie Lazzaro and Hugh Greenwood putting their hand up in the VFL.
Jaidyn Stephenson seems a certainty to be axed once again, while plenty of players had no impact against the Saints including Jackson Archer, Riley Hardeman and Toby Pink.
Collingwood vs. West Coast teams
The Magpies will still be without midfield guns Jordan De Goey (groin) and Tom Mitchell (appendix), while Brody Mihocek is out for three weeks with a hamstring injury.
Beau McCreery has also entered concussion protocols, Lachie Schultz is suspeneded while Jamie Elliott (back) could be rested.
This means three or four Collingwood players will come out of their forward line with Ash Johnson, Reef McInnes and Joe Richards all looking likely for selection.
Finlay Macrae appears unlucky to still be in the VFL and could be injected into the Magpie midfield.
West Coast have their own injury performers with top performers Elliot Yeo (groin) and Jake Waterman (concussion) ruled out.
It's likely Ryan Maric and Jayden Hunt will return for the two injured stars.
Adelaide vs. Brisbane teams
After an excellent win against rivals Port Adelaide, it's unlikely Adelaide will make too many changes.
Any selection chat will likely be in the forward line with Elliott Himmelberg to come under threat from the SANFL form of Chris Burgess and Lachlan Gollant.
It's an injury nightmare in Brisbane with both Lincoln McCarthy and Darcy Gardiner tearing their ACL's, while Brandon Starcevich will miss at least a month with a calf issue and Noah Answerth has entered concussion protocols.
Jarryd Lyons should earn another recall as he yo-yo's between VFL and senior level, while Jaxon Prior and James Tunstill should also come under consideration.
