The Premier League appears to be beyond Tottenham now. If Chelsea defeat West Brom on Friday they will be crowned champions, as Spurs were beaten 1-0 by West Ham United at London Stadium last week.
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However, this week's clash with Manchester United is a massively important one; this will be the final ever game that takes place at White Hart Lane before Spurs move into Wembley for next season, and the "new" White Hart Lane the campaign thereafter.
Thus, Spurs fans will feel that this is a must-win encounter. Mauricio Pochettino's men can also all but confirm their second-placed finish in the Premier League table with a victory.
TOTTENHAM INJURIES
Despite previous optimistic reports to the contrary, Danny Rose has yet to return to the first-team action.
The left-back was forecast to play against Arsenal but was not included in the squad, while he was also left out against West Ham.
He remains a major doubt to play against Manchester United, with Ben Davies likely to continue to deputise, and it is unlikely he will return prior to the end of the season.
Elsewhere, Erik Lamela and Harry Winks are on the long-term injury list.
TOTTENHAM SUSPENSIONS
Spurs have no players suspended for the encounter with Manchester United.
POTENTIAL TOTTENHAM LINE-UP
Spurs have enjoyed immense success this season without ever completely overhauling their starting line-up.
While the side were disappointing against West Ham - with Harry Kane completely nullified by a superb defensive display from Slaven Bilic's men - Mauricio Pochettino is unlikely to tweak his line-up too much.
Kyle Walker played against West Ham, thus logic dictates that Kieran Trippier is likely to start at right-back, with Pochettino regularly swapping his full-backs.
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Mousa Dembele did not play at London Stadium and was clearly missed, with Eric Dier and Victor Wanyama deployed in midfield in a 4-2-3-1 formation.
Thus, a return to the 3-4-2-1 formation that has seen Spurs challenge for the title is likely, with Dembele restored to the midfield and Dier dropping back into defence.
MANCHESTER UNITED DOSSIER
United have prioritised the Europa League over anything else this season, and it remains to be seen if they will decide to rest players against Spurs.
Jose Mourinho's men squeaked into the final with a 2-1 aggregate win over Celta Vigo and will play Ajax in the showpiece, but they were one-paced throughout the game and struggled to create anything offensively.
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Ashley Young is a doubt for the game with a hamstring injury, while Luke Shaw, Zlatan Ibrahimovic, Timothy Fosu-Mensah and Marcos Rojo are definitely out.
Mourinho rested the likes of David de Gea, Juan Mata, Anthony Martial and Wayne Rooney against Vigo, the latter only making a substitute appearance in the 86th minute, so all could feature against Spurs, but rotation could take place in defence, with Eric Bailly collecting a red card in the latter stages of Thursday's nervy encounter.
BEST OPTA MATCH FACTS
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Spurs' only win in their last 15 Premier League games against Manchester United came in last season's 3-0 victory (D6 L8).
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Jose Mourinho has failed to win on his last four Premier League visits to White Hart Lane (D2 L2) and hasn't won a league game there since August 2005, when his Chelsea side defeated Spurs 2-0.
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Spurs have won their last 13 home league matches - one short of their club record run of 14 between January and October 1987.
TV COVERAGE & KICK-OFF TIME
The game is due to kick off at 16:30 on Sunday and will be televised live on Sky Sports in the UK.