Antonio Conte has selected Nemanja Matic over Cesc Fabregas for Chelsea's potentially record-equalling clash at Tottenham.
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Matic is one of two changes for the Premier League leaders, with Pedro also returning after suspension to replace Willian.
Tottenham, meanwhile, welcome back Kyle Walker and Jan Vertonghen following their own one-match bans while Moussa Dembele comes in for Heung-Min Son.
A win for Chelsea at White Hart Lane would see them equal Arsenal's record of 14 successive top-flight victories set by the Gunners in 2002.
But Spurs have been in impressive form themselves, with Mauricio Pochettino's side having won their last matches 4-1 over Southampton and Watford.
Tottenham: Lloris; Dier, Alderweireld, Vertonghen; Walker, Dembele, Wanyama, Rose; Eriksen, Alli; Kane.
Chelsea: Courtois; Azpilicueta, David Luiz, Cahill; Moses, Matic, Kante, Alonso; Pedro, Costa, Hazard.