Richard Scudamore is to leave the Premier League after almost 20 years as the organisation's executive chairman.
Scudamore, who will step down by the end of 2018, helped to build the Premier League into one of football's most dominant bodies, overseeing massive increases in revenues and attendances.
A report released by Deloitte’s Sports Business Group in April found Premier League clubs' combined revenue increased to a record £4.5 billion ($6bn) in the 2016-17 season.
"It's an absolute privilege to have been allowed to enjoy this role for so long, it is too much fun to be called a job," Scudamore said in a statement.
"Football is an intoxicating environment and therefore difficult to give up being so involved, but my passion for what football means to so many and the positive impact it can make will never diminish."
He added: "This past 20 years would not have been possible without the continuing support and encouragement of the clubs and the unstinting efforts of my colleagues at the Premier League.
"We could not have achieved so much without the enormous commitment of broadcast and commercial partners across the world. That number will run into hundreds. They have all contributed to our story and I would like to thank them enormously."
Chelsea chairman Bruce Buck, who heads the Premier League's audit and remuneration committee, has revealed that the search for Scudamore's successor is already underway.
"We expect to make an appropriate appointment in good time so there can be a seamless transition," he said.
"I speak for all the clubs when I say we are very sorry that Richard will be leaving, but we could not have asked for anything more from him. For 20 years he has led the Premier League with distinction.
"Whilst probably best known for the outstanding growth he has delivered, most importantly he commands the respect of everyone in football for the dignified and positive way he has managed the complexities of keeping the league together and moving us forward.
"The Premier League certainly will go on from strength to strength; we also hope that Richard enjoys a very healthy and successful future.
"When he eventually leaves later in the year it will be with our sincerest thanks and gratitude for a job well done."