It has finally arrived — Week 1 of the 2024 NFL season is here! The Sporting News has every betting line you need to know for the opening-week slate, including moneyline, spread, and over/under odds for every game.
The 59th season in the Super Bowl era kicks off on Thursday when Patrick Mahomes and the defending champion Chiefs host reigning MVP Lamar Jackson and the Ravens.
MORE: NFL best bets against the spread | Week 1 power rankings
Then on Friday, the Packers take on the Eagles in the league's first-ever Brazilian game in São Paulo. Then the NFL takes a breather to allow for NCAA to dominate Saturday before a dozen more games kick off on the Sunday slate.
The Rams and Lions face off in a playoff rematch on Sunday night, then Aaron Rodgers and the Jets visit Christian McCaffrey and the defending NFC-champion 49ers in Santa Clara on Monday night.
Got all that!? Good! Now let's look at how oddsmakers think those 16 games will shake out. Here are the full odds for every Week 1 game of the 2024 NFL season. Good luck, have fun, and may all your close bets fall in your favor!
NFL Week 1 odds: Lines, spreads, over/under totals
All odds courtesy of BetMGM.
| Day/time (ET) | Game | ML | ATS | O/U |
| Thu., 8:20 p.m. | Ravens @ Chiefs | KC -150 BAL +125 | KC -3 (-105) BAL +3 (-115) | O 46 (-110) U 46 (-110) |
| Fri., 8:15 p.m. | Packers @ Eagles (Brazil) | PHI -150 GB +125 | PHI -2.5 (-120) GB +2.5 (+100) | O 48.5 (-115) U 48.5 (-105) |
| Sun., 1:00 p.m. | Jaguars @ Dolphins | MIA -165 JAX +140 | MIA -3 (-120) JAX +3 (+100) | O 49.5 (-110) U 49.5 (-110) |
| Sun., 1:00 p.m. | Steelers @ Falcons | ATL -150; PIT +125 | ATL -3 (-110) PIT +3 (-110) | O 42 (-110) U 42 (-110) |
| Sun., 1:00 p.m. | Vikings @ Giants | MIN -120; NYG +100 | MIN -1.5 (-110) NYG +1.5 (-110) | O 41.5 (-110) U 41.5 (-110) |
| Sun., 1:00 p.m. | Panthers @ Saints | NO -200 CAR +165 | NO -4 (-110) CAR +4 (-110) | O 41.5 (-110) U 41.5 (-110) |
| Sun., 1:00 p.m. | Patriots @ Bengals | CIN -400; NE +310 | CIN -9 (-110) NE +9 (-110) | O 40.5 (-110) U 40.5 (-110) |
| Sun., 1:00 p.m. | Titans @ Bears | CHI -210 TEN +170 | CHI -4.5 (-110) TEN +4.5 (-110) | O 45.5 (-110) U 45.5 (-110) |
| Sun., 1:00 p.m. | Cardinals @ Bills | BUF -250 ARI +200 | BUF -6 (-110) ARI +6 (-110) | O 48.5 (-110) U 48.5 (-110) |
| Sun., 1:00 p.m. | Texans @ Colts | HOU -140; IND +115 | HOU -2.5 (-110) IND +2.5 (-110) | O 49 (-110) U 49 (-110) |
| Sun., 4:05 p.m. | Raiders @ Chargers | LAC -160; LV +135 | LAC -3 (-115) LV +3 (-105) | O 40.5 (-110) U 40.5 (-110) |
| Sun., 4:05 p.m. | Broncos @ Seahawks | SEA -250 DEN +200 | SEA -6 (-110) DEN +6 (-110) | O 42 (-110) U 42 (-110) |
| Sun., 4:05 p.m. | Commanders @ Bucs | TB -165 WAS +140 | TB -3 (-115) WAS +3 (-105) | O 43.5 (-110) U 43.5 (-110) |
| Sun., 4:25 p.m. | Cowboys @ Browns | CLE -140 DAL +115 | CLE -2.5 (-115) DA: +2.5 (-105) | O 42.5 (-110) U 42.5 (-110) |
| Sun., 8:20 p.m. | Rams @ Lions | DET -175 LAR +145 | DET -3.5 (-105) LAR +3.5 (+145) | O 51 (-110) U 51 (-110) |
| Mon., 8:20 p.m. | Jets @ 49ers | SF -200; NYJ +165 | SF -4 (-110) NYJ +4 (-110) | O 42.5 (-110) U 42.5 (-110) |
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