Many bettors had a profitable Week 10 thanks to six underdogs winning outright (Vikings, Lions, Steelers, Colts, Packers, and Cardinals). Out of the six teams that pulled off upsets, the Vikings provided the most ROI, as they were +275 on the moneyline. Gamblers are looking to capitalize off a successful week and carry it into Week 11 where a host of new opportunities await for us on the moneyline, against the spread, and in terms of over/unders.
Week 11 begins with Derrick Henry and the Titans heading to Lambeau Field to play the Packers on Thursday Night Football. Tennessee is coming off a hard-fought 17-10 win over the Broncos, while Green Bay snapped its five-game losing streak with an overtime win over the Cowboys. After that, we have a solid 12-game slate on Sunday, which includes Cowboys-Vikings, Browns-Bills, and Chiefs-Chargers on Sunday Night Football.
To wrap up Week 11, the 49ers and Cardinals will face off against each other in Mexico City in the NFL's final international series game of 2022. San Francisco has won back-to-back games after defeating the Chargers on Sunday Night Football in Week 10. Meanwhile, the Cardinals snapped their two-game losing skid in Week 10 with a 10-point win over the Rams despite no Kyler Murray.
Please remember that the odds and lines will move throughout the week as we get updates on various injuries across the league. There could be some opportunity for closing line value (CLV) in a few games leading up to kickoff. Below, we take a look at the latest odds for Week 11 from BetMGM and provide a few best bets that need to be on your radar.
NFL odds Week 11
| Game | Spread |
| Tennessee Titans at Green Bay Packers | GB -3 |
| Chicago Bears at Atlanta Falcons | ATL -2.5 |
| Cleveland Browns at Buffalo Bills | BUF -7.5 |
| Philadelphia Eagles at Indianapolis Colts | PHI -6.5 |
| New York Jets at New England Patriots | NE -3.5 |
| Los Angeles Rams at New Orleans Saints | NO -2.5 |
| Detroit Lions at New York Giants | NYG -3.5 |
| Carolina Panthers at Baltimore Ravens | BAL -12.5 |
| Washington Commanders at Houston Texans | WSH -3 |
| Las Vegas Raiders at Denver Broncos | DEN -2.5 |
| Dallas Cowboys at Minnesota Vikings | DAL -1.5 |
| Kansas City Chiefs at Los Angeles Chargers | KC -5.5 |
| Cincinnati Bengals at Pittsburgh Steelers | CIN -3.5 |
| San Francisco 49ers at Arizona Cardinals | SF -8 |
NFL moneylines Week 11
| Game | Moneyline |
| Tennessee Titans at Green Bay Packers | TEN +120 | GB -145 |
| Chicago Bears at Atlanta Falcons | CHI +120 | ATL -145 |
| Cleveland Browns at Buffalo Bills | CLE +275 | BUF -350 |
| Philadelphia Eagles at Indianapolis Colts | PHI -300 | IND +240 |
| New York Jets at New England Patriots | NYJ +145 | NE -175 |
| Los Angeles Rams at New Orleans Saints | LAR +120 | NO -145 |
| Detroit Lions at New York Giants | DET +135 | NYG -165 |
| Carolina Panthers at Baltimore Ravens | CAR +525 | BAL -750 |
| Washington Commanders at Houston Texans | WSH -165 | HOU +140 |
| Las Vegas Raiders at Denver Broncos | LV +120 | DEN -145 |
| Dallas Cowboys at Minnesota Vikings | DAL -120 | MIN +100 |
| Kansas City Chiefs at Los Angeles Chargers | KC -250 | LAC +200 |
| Cincinnati Bengals at Pittsburgh Steelers | CIN -200 | PIT +165 |
| San Francisco 49ers at Arizona Cardinals | SF -350 | AZ +280 |
NFL over/unders Week 11
| Game | Over/Under |
| Tennessee Titans at Green Bay Packers | 42 |
| Chicago Bears at Atlanta Falcons | 48.5 |
| Cleveland Browns at Buffalo Bills | 50.5 |
| Philadelphia Eagles at Indianapolis Colts | 45 |
| New York Jets at New England Patriots | 38 |
| Los Angeles Rams at New Orleans Saints | 39.5 |
| Detroit Lions at New York Giants | 45 |
| Carolina Panthers at Baltimore Ravens | 41.5 |
| Washington Commanders at Houston Texans | 41 |
| Las Vegas Raiders at Denver Broncos | 41.5 |
| Dallas Cowboys at Minnesota Vikings | 48.5 |
| Kansas City Chiefs at Los Angeles Chargers | 52.5 |
| Cincinnati Bengals at Pittsburgh Steelers | 39.5 |
| San Francisco 49ers at Arizona Cardinals | 43.5 |
NFL best bets for Week 11
*Odds as of Monday*
Bears at Falcons OVER 49.5 points
Many bettors will take the Bears' spread based on how they've played the past month with Justin Fields blossoming before our eyes. However, the best play in this matchup is the OVER on the total. The Bears' offense has found a spark, scoring at least 30 or more points in three of its past four games. Fields has played a huge role in the offense's newfound life, as the Bears' running game has been explosive. However, Chicago's defense has not been great over that time, giving up 32.2 points per game. The Falcons should be able to create some big plays with Cordarrelle Patterson, Kyle Pitts, and Drake London if Marcus Mariota doesn't turn over the ball. The Bears' O/U record is 6-4, while the Falcons' record is 5-5. Additionally, the OVER is 5-1 after a loss for Chicago and 3-2 after a loss for Atlanta this season.
Jets (+3) at Patriots
The Jets have proven the doubters wrong this season, sitting three games above .500 (6-3). Robert Saleh's crew has a tough matchup on Sunday against the Patriots in Foxboro, but bettors should not be scared of taking New York to cover. This season, the Jets are 4-0 on the road with an average margin of victory of 7.2 points. They are also 4-0 against the spread on the road and 5-3 ATS as the underdog this season. In their first meeting in Week 8, the Pats won 22-17, but some untimely INTs undid Zach Wilson and the Jets' offense. Neither starting quarterback in this matchup is great, so it should be a close, defensive battle.
Lions at Giants UNDER 46.5 points
This game features one of the best OVER teams in the Lions and one of the better UNDER teams in the Giants. New York's calling card has been its defense, which is giving up 19.6 points per game. In fact, the Giants have not allowed a team to score 20 or more points since Week 6. Meanwhile, Detroit scores a good amount (24.3 ppg) but gives up even more (29.3). However, we saw the Lions play to a 15-9 outcome just two weeks ago against Green Bay. I don't think we see a high-scoring affair Sunday, as the Giants' defense will pressure Jared Goff and force him to get the ball out quickly. The UNDER has hit in seven out of New York's nine games and four out of five home games this season, so we're expecting the Giants to set the pace and slow the game down.
