INDIANAPOLIS — Andrew Luck and Reggie Wayne were back in sync for Indianapolis on Sunday.
The 25-year-old quarterback threw for 393 yards and four touchdowns, while the 35-year-oldColts receiver had seven catches for a season-best 119 yards and his first TD of the season, leading the Colts to a 41-17 rout over Tennessee.
MORE: Follow live NFL scores and stats | Best of NFL Week 4 photos
Luck finished 29 of 41 with a season-high 393 yards and has thrown for eight TDs and 763 yards in the past two weeks.
T.Y. Hilton had six receptions for 105 yards as Indy (2-2) extended its league-best winning streak over in-division foes to nine.
Wayne turned his 200th career game into a showcase. He passed Isaac Bruce for seventh on the NFL's career receptions list, Henry Ellard for 10th in career yards receiving and extended his NFL record for consecutive games with three or more catches to 75. Wayne now has 1,029 catches, 13,873 yards and capped the day with a spectacular, spinning touchdown that gave the Colts control midway through the third quarter.
Tennessee (1-3) never had a chance with starting quarterback Jake Locker out because of a right wrist injury.
Charlie Whitehurst, a nine-year veteran, made his fifth career start. Though he didn't play badly, he was yanked midway through the fourth quarter with the Titans trailing 41-17. Whitehurst finished 12 of 23 for 177 yards with one TD and one interception. He rushed five times for 40 yards.
Tennessee failed to score in the first quarter for the fourth consecutive week and couldn't reach the end zone until Whitehurst threw a 7-yard TD pass to Delanie Walker with 13 seconds left in the half to make it 20-10. It was the fourth TD of Whitehurst's career.
Wayne's incredible catch, on which he was able to maintain his balance on the sideline, gave the Colts a 27-10 lead. Luck sealed it with a 2-yard TD pass to Coby Fleener with 4:02 left in the third. That made it 34-10.
Luck wasted no time in giving the Colts the lead.
Two plays after the Colts recovered a Kendall Wright fumble, Trent Richardson completed the 38-yard drive with a 1-yard TD run.
Pat McAfee followed that with a surprise onside kick that Indy recovered. Elven plays later, Luck found Dwayne Allen for a 7-yard TD catch to make it 14-0.
Indy held the ball for more than 42 minutes.