When the Bills (4-1) take on the Titans (3-2) in Nashville to close Week 6 in the NFL on Monday night (8:15 p.m. ET, ESPN), they will look to match the Ravens (5-1) for the best record in the AFC. The Titans will be hoping to put more distance between them and the weak AFC South opponents.
Josh Allen and Buffalo are coming off an emotional victory in Kansas City. Ryan Tannehill and Tennessee came through a get-well win in Jacksonville in Week 5.
The Bills' defense is playing at a high level. The Titans' defense isn't, but it can be helped playing behind a loud crowd in prime time.
Here's everything to know about betting on Bills vs. Titans in Week 6, including updated odds, trends and our prediction for "Monday Night Football."
Bills vs. Titans odds for 'Monday Night Football'
- Spread: Bills by 5.5
- Over/under: 53.5
- Moneyine: Bills -245, Titans +200
(betting odds per FanDuel Sportsbook)
The line has stayed like this all week leading up to the game. The Bills would have been heavy favorites at home. The over/under reflects the potency of both offenses by different means.
Bills vs. Titans all-time series
The Titans, who used to be the Oilers, own the advantage at 29-19. The Titans crushed the Bills at home 42-16 last Oct. 13. Before then the Bills had won three straight, including 14-7 in Nashville in 2019.
Three trends to know
—Nearly 80 of spread bettors believe the Titans will make it a game at home and have the night underdogs covering.
—Only 53 percent of over/under bettors think the game will finishing higher than its projected point total taking into account defensive overachieving.
—The Bills are 8-2 straight up and 7-3 against the spread in the past 10 games with five of the games going over. The Titans are 6-4 SU and 5-5 ATS in their past 10 games with six of the games going over.
Three things to watch
Bills wide receivers vs. Titans cornerbacks
Stefon Diggs and Emmanuel Sanders on the outside should have big games given one starter, Kristian Fulton, isn't playing, and the other is Janoris "Jackrabbit" Jenkins, who isn't good anymore. The Titans also have been vulnerable in the slot, giving some better chances for Cole Beasley.
Titans wide receivers vs. the Bills cornerbacks
This is a brutal matchup for A.J. Brown and Julio Jones, together again after different bouts with hamstring injuries. Perimeter corners Tre'Davious White and Levi Wallace are playing well and getting big-time help from Taron Johnson in the slot. Brown and Jones need to use their size and strength to help Tannehill when it won't be easy in coverage.
Derrick Henry vs. the Bills
Henry has been contained in the past by the Bills' defense. In three meetings, he has only 191 rushing yards and 3 TDs while averaging only 3.8 yards per carry. He's been a non-factor in the passing game, with only one catch for 6 yards.
Stat that matters
78.4. That's how many rushing yards on average the Bills have given up this season. That was good for No. 3 in the NFL going into Week 6. They also have been allowing only 3.7 yards per carry. That should help them slow down Henry and therefore in time, the play-action passing game with Tannehill.
Bills vs. Titans prediction
The Bills will play well again to drop another former AFC playoff-level nemesis on the road. The Titans will show some fight at home under Mike Vrabel, but Buffalo's defense will put down the clamps when needed for Sean McDermott. Tannehill simply can't keep up with Allen even with his weapons healthy.
Bills 27, Titans 23