The Bears will be without their best offensive weapon with the Broncos' top-ranked defense in town Sunday.
Bears wide receiver Alshon Jeffery, who has been battling groin and shoulder injuries, is inactive and won't play against the Broncos, the team announced.
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Jeffery practiced Wednesday before sitting out the team's final two practices and was listed as questionable on the team's injury report. He had spent most of training camp on the sideline with a calf injury but played in Chicago's opener against Green Bay, though he missed the next four games with a hamstring injury.
Jeffery struggled in last Sunday's win over the Rams as he played about half the snaps, but boasted terrific performances in his first three games back from injury. He logged 29 catches for 414 yards and two touchdowns against the Lions, Vikings and Chargers. With fellow wideout Eddie Royal also ruled out, the Bears will turn to Marquess Wilson, Josh Bellamy and Marc Mariani to fill the void. Versatile running back Matt Forte is also inactive.
Meanwhile, the Broncos are dealing with their share of injuries, as wide receiver Emmanuel Sanders is listed as inactive with ankle and finger injuries. Backup quarterback Brock Osweiler will make his first career start with one less target as veteran Peyton Manning heals from a partially torn plantar fascia in his left foot. Also, linebacker DeMarcus Ware is inactive for the third time this season as he deals with a back injury.