The winless Falcons have fired head coach Dan Quinn and general manager Thomas Dimitroff, the team announced.
Sunday's 23-16 loss to the Panthers proved the final straw for Atlanta's hierarchy following an 0-5 start to the season.
Quinn compiled a 43-42 record since the start of the 2015 season, including a painful loss to the Patriots in Super Bowl 51 after squandering a 28-3 lead. Dimitroff joined the Falcons in 2008.
The Falcons, who are scheduled to face the Vikings on the road in Week 6, are set to announce an interim coach Monday.
BREAKING NEWS: General Manager Thomas Dimitroff and Head Coach Dan Quinn have been relieved of their duties, effective immediately.
— Atlanta Falcons (@AtlantaFalcons) October 12, 2020
"Decisions like these are very difficult, but the previous two seasons and start to this one have been especially hard for me because of the deep love, admiration and respect I and my family have for Dan, Thomas and their families," Falcons owner and chairman Arthur Blank said.
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"For many years, they have represented me, our team, organization and Atlanta with class, commitment and all the passion you would want in the leaders of the team. But as everyone knows, this is a results business and I owe it to our fans to put the best product we can on the field. We have poured every resource possible into winning and will continue to do so, but the results of late do not meet our standard or what I've promised our fans. Therefore, we will install new coaching and personnel leadership of the Atlanta Falcons at the appropriate time.
"Our finish in 2019 earned an opportunity to show that momentum could be continued and built upon, but that has clearly not happened," Blank continued. "And overall, the last three-plus seasons have fallen short of my commitment to Atlanta and to our fans everywhere. I want them all to know that my commitment to winning has not wavered and I will continue to provide every resource possible to that end."
Falcons president and chief executive Rich McKay added: "We are moving forward and will do everything we can to help this year's team win as many games as possible while putting a strong plan in place to execute these important leadership searches with an eye to positioning the Falcons for success well into the future. We owe that to our fans."