The Cardinals have won the NL Central in each of the last three years, but oddsmakers are calling for the Cubs to dethrone St. Louis and captured the division for the first time since 2008.
Bovada has full odds on all the divisional winners, with the Mets and Cubs both at minus-money. The American League divisions are much more wide-open with so many teams rebuilding in the National League.
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Be sure to calculate the juice on futures markets like these to make sure you're getting a fair price. Here's an explainer on how to do it.
MLB divisional betting odds
AL East
Red Sox +160
Blue Jays +160
Yankees +350
Orioles +900
Rays +900
AL Central
Royals +110
Indians +250
Tigers +400
White Sox +600
Twins +1000
AL West
Astros +160
Rangers +210
Angels +375
Mariners +400
Athletics +1200
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NL East
Mets -110
Nationals +110
Marlins +600
Braves +2500
Phillies +3300
NL Central
Cubs -150
Cardinals +250
Pirates +300
Reds +2500
Brewers +2500
NL West
Giants +125
Dodgers +150
Diamondbacks +300
Padres +1200
Rockies +5000