Manchester City centre-back John Stones could miss up to six weeks after leaving Saturday's match against Leicester City with a hamstring issue.
The England defender pulled up clutching his hamstring 28 minutes into the contest at the King Power Stadium, and had to be replaced by Eliaquim Mangala.
Watford 13/2 to beat West Ham 1-0
28. Concerns for John Stones who's pulled up in pursuit of the ball. Looks like his hamstring and that could be John's game over
— Manchester City (@ManCity) November 18, 2017
0-0 #foxesvcity
The 23-year-old initially appeared to be suffering discomfort in his hamstring during England's friendly with Brazil on Tuesday, and his injury on Saturday seemed to be a continuation of that problem.
In his post-match press conference, Pep Guardiola confirmed the 23-year-old is set for an extended spell on the sidelines.
"It is unfortunate for us and for John and I think he might be out for six weeks with that type of injury," Guardiola said.
"We don't have a lot of central defenders, but the spirit in the team – and with all the players – is good so we are going to find a solution."
Vincent Kompany made his own return from injury on Saturday and he looks set to be given a run of games in the centre of high-flying City's defence.
City would go on to defeat Leicester 2-0 thanks to goals from Gabriel Jesus and Kevin De Bruyne – the club's 10th straight league win.