Sportsbooks opened betting on NFL Week 1 odds after the 2024-25 NFL schedule was released last week.
The season opens on Thursday, September 5 with the Chiefs hosting the Ravens. The Packers and Eagles follow on September 6 in Brazil.
The first Monday Night Football game of the 2024 season features the Jets vs. 49ers.
Here we examine NFL Week 1 odds on top sportsbook apps.
Where to bet 2024 NFL Week 1 odds
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2024 NFL Week 1 odds: Point spread, moneyline, total
Let's start with Ravens vs. Chiefs odds at top-rated sportsbooks for the NFL season opener, followed by the rest of the Week 1 games, with some analysis of a select few.
Ravens vs. Chiefs odds
The Ravens added a big name in RB Derrick Henry during the offseason. Henry should complement Lamar Jackson well and reduce the number of carries for his quarterback.
There were a couple key losses on defense with linebackers Patrick Queen and Jadeveon Clowney moving on to Pittsburgh and Carolina, respectively.
Baltimore won the AFC North title at 13-4 and saw its season come to an end in the AFC Championship game won by Kansas City, 17-10.
The Chiefs captured their second consecutive Super Bowl with a 25-22 win over the 49ers. Kansas City bolstered its wide receiving corps with the addition of former Baltimore WR Hollywood Brown. The Chiefs also drafted Texas WR Xavier Worthy in the first round.
Rashee Rice, KC's top wideout last season, is expected to be suspended by the NFL after his involvement in a reckless driving incident. Defensively, Kansas City locked down DT Chris Jones with a new five-year contract. The Chiefs did lose the services of top CB L'Jarius Sneed, who left to join the Titans.
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Packers vs. Eagles odds
The NFL's first game in Brazil will also be the first matchup played on a Friday since 1970. The Eagles opened at -3.5, but the line's been trimmed to -1.5 at sportsbooks including BetMGM.
This game will mark the debut of RB Saquon Barkley in a Philadelphia uniform. The Eagles also added pass-rushing specialist Bryce Huff from the Jets. Green Bay's biggest offseason acquisitions included safety Xavier McKinney and running back Josh Jacobs.
Philadelphia lost six of its last seven games to end last season. Green Bay, under the direction of new quarterback Jordan Love, throttled Dallas 48-32 in the opening round of the playoffs before losing to San Francisco 24-21 in the divisional round.
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Titans vs. Bears odds
No. 1 overall pick Caleb Williams opens the season at home, as the Bears and their re-tooled offense take on the Titans, who will be under a new coach and with a new identity following Henry's offseason departure.
Steelers vs. Falcons odds
Kirk Cousins and Russell Wilson will open their stints with new teams against one another. Atlanta rates the edge here in skill position players as Cousins is joined by RB Bijan Robinson, TE Kyle Pitts and WR Drake London.
Jaguars vs. Dolphins odds
Tua Tagovailoa and Tyreek Hill are set to return as a lethal pass-catch combination for the Dolphins, who added Penn State defensive standout Chop Robinson in the NFL Draft. The Jags shored up their interior defense with the addition of former San Francisco DT Arik Armstead.
Patriots vs. Bengals odds
Welcome to head coaching, Jerod Mayo. In your first game taking over for the GOAT, you get to be the biggest underdog on the Week 1 slate.
Texans vs. Colts odds
AFC South rivals meet in Week 1, with reigning Rookie of the Year CJ Stroud looking to start his second season as hot as he finished his first.
Vikings vs. Giants odds
The Vikings could use a "W" against the Giants here in the opener with three tough games to follow including a matchup with the 49ers in Week 2. Rookie QB J.J. McCarthy is likely to start at QB after Kirk Cousins went to Atlanta. The Giants landed a premier pass-rushing specialist in former Carolina DE/LB Brian Burns.
Panthers vs. Saints odds
It's the only game in Week 1 to have a total open below 40, and most of the juice is on the UNDER.
Cardinals vs. Bills odds
With Stefon Diggs gone to Houston, the Bills did pick up former Washington WR Curtis Samuel. They also selected FSU WR Keon Coleman in the draft. TE Dalton Kincaid will also be a top receiving threat. Arizona landed former OSU WR Marvin Harrison Jr. with the fourth pick of the 2024 NFL Draft.
Raiders vs. Chargers odds
Harbaugh!
Commanders vs. Buccaneers
Former Chargers RB Austin Ekeler joined Washington in the offseason. The Commanders drafted LSU QB Jayden Daniels in the first round. The Buccaneers retained QB Baker Mayfield and WR Mike Evans with new multi-year deals.
Cowboys vs. Browns odds
The Browns opened as a 1-point favorite over the Cowboys at some books, and the line had even moved to a pick 'em at Caesars Sportsbook.
The Cowboys lost top running back Tony Pollard, and then re-signed former bell-cow RB Ezekiel Elliott to join QB Dak Prescott and WR CeeDee Lamb. Linebacker Eric Kendricks was another key offseason addition. Dallas took two offensive lineman in the draft. First round pick Tyler Guyton (left tackle) and third-round selection Cooper Beebe (center) are expected to start this season.
Dallas is coming off another solid regular season at 12-5, but the Cowboys crashed and burned in the opening round of the playoffs in a 48-32 loss to the Packers.
Cleveland added QBs Jameis Winston and Tyler Huntley along with RB D'Onta Foreman and WR Jerry Jeudy. Starting QB Deshaun Watson has only played in 12 games since signing with the Browns.
Cleveland captured a wildcard berth last year with an 11-6 record before getting drilled by Houston 45-14 in the opening round of the playoffs.
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Broncos vs. Seahawks odds
The Broncos are only favored in two regular season games, and this isn't one of them. Denver needs rookie QB Bo Nix to take command of the offense early and get off to a quick start.
Rams vs. Lions odds
The Sunday Night Football opener is a rematch of this past season's wild card playoff game, which the Lions won in front of one of the loudest crowds in NFL history. It also has the highest total on the slate.
Jared Goff, Amon-Ra St. Brown and Penei Sewell all signed huge extensions in the offseason for Detroit, securing the core of a team that is among the top Super Bowl contenders in the NFL.
The Rams are sure to be a juggernaut on offense again, as Matthew Stafford is back along with all of his weapons. But there's an Aaron Donald-sized hole in the middle of the defense, as the future Hall-of-Famer retired in the offseason. Can a revamped Rams defensive line slow down the Lions prolific attack?
Jets vs. 49ers odds
This is one of the largest spreads on the slate. Aaron Rodgers returns to competition after missing all of last year due to a torn achilles in the season opener. The Jets solidified their offensive line and added a few key players elsewhere. The addition of DE Haason Reddick helps offset the loss of linebacker Bryce Huff, who led New York with 10 sacks a year ago.
Former Chargers WR Mike Williams inked a one-year deal, and he'll give Rodgers another trusted target to throw to along with Garrett Wilson.
The majority of San Francisco's offseason moves involved upgrades on the offensive and defensive lines.
The 49ers still have a wealth of offensive firepower with RB Christian McCaffrey and WR Deebo Samuel. There was a lot of trade speculation involving fellow WR Brandon Aiyuk heading into the draft, but that never came to pass. QB Brock Purdy will also have 30-year-old TE George Kittle back in the fold.
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