Pierre-Emerick Aubameyang returns to the Arsenal line-up against Watford on Sunday.
The Gabon international was cup-tied for the Europa League victory over AC Milan on Thursday, but returns to the fold against the Hornets, with the Gunners aiming to halt a run of three straight Premier League defeats.
Ainsley Maitland-Niles and Mohamed Elneny both come in while Rob Holding starts at centre back in place of rested vice-captain Laurent Koscielny.
Jack Wilshere and Calum Chambers are on the substitutes bench following their midweek exertions while Aaron Ramsey and the aforementioned Koscielny are not in the squad altogether.
Meanwhile, Watford captain Troy Deeney starts upfront after his comments about Arsenal lacking cojones following the 2-1 win at Vicarage Road in October.
Watford benefitted from a penalty decision against the Gunners, and won the match with a last-minute Tom Cleverley goal, and Deeney revelled in the victory afterwards.
"I've heard Wenger's already blaming (the decision) as the reason why they lost," he said at the time. "I'm not going to be the one to tell Mr Wenger about himself, but there's a reason why they lost and it wasn't because of one penalty.
"I'll have to watch what I say. It's (having) a bit of cojones, a bit of nuts."
Gunners boss Arsene Wenger responded ahead of the game, saying: “They got a cheap penalty from a good dive.
"We’ll respond to him on the pitch [on Sunday]."
Arsenal XI: Cech; Maitland-Niles, Holding, Mustafi, Kolasinac; Elneny, Xhaka; Ozil, Iwobi, Mkhitaryan; Aubameyang. Subs: Ospina, Chambers, Willock, Nelson, Wilshere, Nketiah, Welbeck.
Watford XI: Karnezis; Femenía, Prödl, Mariappa, Holebas; Doucouré, Capoue; Janmaat, Pereyra, Richarlison; Deeney. Subs: Bachmann, Britos, Hughes, Carrillo, Sinclair, Gray, Okaka.
