It's last-chance saloon on Thursday night for Manchester United's faltering hopes of finishing in the top four in the Premier League and qualifying for the UEFA Champions League in 2022/23.
Saturday's sorry 3-1 reversal at Arsenal has left Ralf Rangnick's side six points behind the fourth-placed London club with only four matches remaining and the Gunners with a game in hand.
United need maximum points from their remaining quartet of games, starting with the visit of Chelsea, and for Arsenal and Tottenham, in fifth, to both drop points if they are to have any chance of getting a top-four place.
Chelsea are not certain of a top-four spot themselves and need nine points from their remaining six games to be sure of their place in the Champions League next season.
LIVE BLOG: Goals, updates and commentary from Man United-Chelsea
What channel is Manchester United vs Chelsea?
| UK | USA | Canada | Australia | |
| Date | Thur, April 28 | Thur, April 28 | Thur, April 28 | Fri, April 29 |
| Time | 19:45 BST | 14:45 ET | 14:45 ET | 04:45 AET |
| TV channel | Sky Sports Premier League, Main Event | USA Network, Universo | — | — |
| Streaming | NOW TV | fuboTV | DAZN | Optus Sport |
UK: The Thursday match will be broadcast in the UK by Sky Sports and streamed on NOW TV.
USA: In the USA, the match will be televised by USA Network (English) and Universo (Spanish) with both channels streamed on fuboTV, which also offers a free trial to new subscribers.
Canada: In Canada, every Premier League game streams live on DAZN.
Australia: The Premier League is carried exclusively by Optus Sport.
Manchester United vs. Chelsea lineups
Fred has returned to training for United, but the Brazilian will not feature against Chelsea as he recovers from a flexor muscle issue that has sidelined him for the past three weeks.
With Paul Pogba, Edinson Cavani and Luke Shaw all ruled out for the rest of the season, and captain Harry Maguire expected to join them, the only change from the side that lost to Arsenal is Marcus Rashford replacing Jadon Sancho, who is unavailable.
Manchester United lineup (4-2-3-1, right to left): 1-De Gea (GK) — 20-Dalot, 2-Lindelof, 19-Varane, 27-Telles — 39-McTominay, 31-Matic — 36-Elanga, 18-Fernandes, 10-Rashford — 7-Ronaldo
Manchester United subs (9): 26-Tom Heaton (GK), 22-Dean Henderson (GK), 3-Eric Bailly, 4-Phil Jones, 74-Alvaro Fernandez, 46-Hannibal Mejbri, 8-Juan Mata, 75-Alejandro Garnacho, 47-Shola Shoretire
Thomas Tuchel made a number of changes on Sunday for the 1-0 win over West Ham as he seeks to keep his players fresh ahead of the FA Cup final on May 14 against Liverpool.
The mixing and matching continues with Reece James returning to the three-man defensive line and Ruben Loftus-Cheek and Trevoh Chalobah relegated to the bench. Match winner Christian Pulisic returns to the subs list as Tuchel continues to rely on the Werner-Mount-Havertz attacking trio.
Chelsea lineup (3-4-3, left to right): 16-Mendy (GK) — 20-Rudiger, 6-Silva, 24-James — 3-Alonso, 5-Jorginho, 7-Kante, 28-Azpilicueta — 11-Werner, 19-Mount, 29-Havertz
Chelsea subs (9): 1-Kepa Arrizabalaga (GK), 31-Malang Sarr, 14-Trevoh Chalobah, 23-Kenedy, 17-Saul Niguez, 12-Ruben Loftus-Cheek, 10-Christian Pulisic, 22-Hakim Ziyech, 9-Romelu Lukaku
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Manchester United vs Chelsea betting odds
United have conceded seven goals in their past two league games and have not kept a clean sheet since February 26.
So Chelsea, who have won their past 10 games away from Stamford Bridge in all competitions, including the FIFA Club World Cup, will fancy their chances of making it 11 in a row on Thursday.
| UK (Sky Bet) | USA (DraftKings) | Canada (Sports Interaction) | |
| [Home] win | 21/10 | +225 | 3.14 |
| Draw | 5/2 | +250 | 3.64 |
| [Away] win | 6/5 | +125 | 2.05 |
| More than 2.5 Goals | 8/11 | -125 | 1.77 |
| Both teams to score | 8/13 | -165 | 1.59 |