Manchester City remain in the running to match Manchester United's 1999 treble this season as they chase glory across three fronts in 2022.
City currently have the edge in the Premier League title race, ahead of facing rivals Liverpool on Sunday, with Pep Guardiola's side leading the way by a single point.
However, the Champions League remains the greatest source of frustration for Guardiola at City, with just one final appearance in five seasons.
Atletico have not reached a Champions League final since their defeat to Real Madrid in 2016 with Diego Simeone's squad also facing a battle to secure a top four finish in La Liga this season.
MORE: Premier League updated table and races
How to watch Manchester City vs. Atletico Madrid
| UK | USA | Canada | Australia | |
| Date | April 5 | April 5 | April 5 | April 6 |
| Time | 20:00 GMT | 15:00 ET | 15:00 ET | 05:00 AET |
| TV channel | BT Sport 2 | CBS, Univision, TUDN | — | — |
| Streaming | BT Sport | fuboTV, Paramount+ | DAZN | Stan Sport |
UK: The match will be available on BT Sport 2 in the UK and streamed on the BT Sport streaming platforms.
USA: CBS (English), Univision and TUDN (Spanish) will all carry the match and all three channels are also available on fuboTV, which also offers a free trial to new subscribers. Paramount+ will also stream the match.
Canada: Every Champions League game in Canada is streamed live and on demand via DAZN.
Australia: Stan Sport streams the Champions League in Australia.
Manchester City vs. Atletico Madrid predicted lineups
Guardiola will be forced into a defensive reshuffle for this game with Ruben Dias still sidelined through injury and Kyle Walker serving the final match of a three-game ban.
John Stones could return as Walker's replacement at right back with Bernardo Silva and Riyad Mahrez also pushing for a recall to the starting XI.
Manchester City predicted lineup (4-3-3): Ederson (GK) — Cancelo, Ake, Laporte, Stones — De Bruyne, Rodri, Silva — Sterling, Foden, Mahrez
Simeone is boosted by the returns of captain Koke and Argentinian forward Angel Correa after they were suspended for their 4-1 league win over Alaves last weekend.
However, he will be forced to wait on last-minute injury news on key defender Jose Maria Gimenez, before naming his starting team at the Etihad.
Atletico Madrid predicted lineup (5-3-2): Oblak (GK) — Lodi, Reinildo, Gimenez, Savic, Vrsaljko — Koke, Kondogbia, Llorente — Griezmann, Felix
MORE: When do Liverpool play Man City?
Manchester City vs. Atletico Madrid betting odds
A Champions League title remains the key objective for Guardiola this season, with the Catalan coach seeking to help City clinch its long-awaited, first-ever European club title.
Defending La Liga champions Atletico edged through the group stages, in second place behind Liverpool. Now Simeone's charges look reignited in 2022 with a Round of 16 win over Manchester United showing all the hallmarks of a trademark Simeone performance.
| UK (Sky Bet) | USA (DraftKings) | Canada (Sports Interaction) | |
| Man City Win | 1/3 | -290 | -345 |
| Draw | 4/1 | +425 | +423 |
| Atletico Win | 17/2 | +900 | +800 |
| Over 2.5 Goals | 8/11 | -115 / -105 | -119 / -106 |
| Both Teams to Score | 11/10 | +115 / -150 | +121 / -192 |
