Jose Mourinho said it would be like having "two new players" as he confirmed Hugo Lloris and Ben Davies should be back in action for Tottenham by the end of January.
Spurs are going through a difficult period, having won only once in their past five matches and lost key players Harry Kane and Moussa Sissoko to serious injuries.
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But head coach Mourinho is expecting to have first-choice goalkeeper Lloris and left-back Davies on the pitch by the end of January.
Lloris suffered an elbow injury at the start of October, meaning Paolo Gazzaniga has had to deputise, while Davies has been missing since sustaining ankle ligament damage in Mourinho's first match at the helm on November 23.
"The good news is that before the end of the month we have two new players, Hugo Lloris and Ben Davies. This is good news," Mourinho said in Friday's news conference ahead of facing Liverpool.
"Lloris never played a game for me, Ben played one, and very, very well in a system we were trying to develop, which was only possible with him because he's the one left-back that can play in that inside position, as Danny Rose is a pure left-back, Jan Vertonghen is not a left-back and Ryan Sessegnon is learning how to be a left-back.
"So, Ben is very important for our project. So, it's good news.
"[Lloris' return] is very important. He's the captain with Harry. We lose one, it's nice to recover the other.
"The experience, the way he plays, speaking - it's very important for a goalkeeper to play and speak at the same time.
"We have a goalkeeper that's doing his best and we have confidence in him. For Hugo to be back after such an important injury is good and it opens space in the medical department.
"Some people are leaving the medical room, some people are coming in. Is there an area in the medical department with a plate saying Hugo Lloris? Because he's there every day for the past three months."
Tottenham, who sit sixth in the Premier League table, face a daunting task on Saturday when they welcome runaway leaders Liverpool to Tottenham Hotspur Stadium.