Ajax coach Erik ten Hag believes Real Madrid will feel the absence of "boss" Sergio Ramos in the second leg of their Champions League tie.
Ramos, 32, is suspended for Tuesday's clash at the Santiago Bernabeu, a last-16 tie Madrid lead 2-1 on aggregate.
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The defender was given a two-match ban by UEFA, which found he had deliberately been booked in Amsterdam.
As a result, he'll miss not only the second leg, but a potential quarterfinal opener should Real Madrid seal their spot in the next round.
Ten Hag feels Madrid will miss the centre-back, saying: "Sergio is the boss on the pitch and in the backline.
"His absence is not only a tactical loss for them, but also mentally.
"His absence is a loss to Madrid. It is clear that without Ramos they are not going to be a better team."
Training session Estadio Santiago Bernabéu! #UCL #reaaja pic.twitter.com/llF6aj8qwI
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Ten Hag wants Ajax to try to control the second leg in the Spanish capital as they aim to cause a huge upset.
"This Ajax takes the initiative in every game against every opponent. At least we have the intention to do so," he said.
"We managed to do so nearly every time."
Ajax's own star defender, Matthijs de Ligt, will be involved and Ajax great Johnny Rep believes the centre-back should stay with the Eredivisie giants for another year.
The club currently sits five points behind PSV Eindhoven in the league, although they do currently maintain a game in hand
Following the Champions League second leg against Real, Ajax will face Fortuna Sittard in their return to Eredivisie play.