Liverpool face off against reigning Serie A Champions Inter Milan in a UEFA Champions League Round of 16 series which pairs two historically successful European clubs.
The Reds are six-time winners of the competition, hoisting their last trophy in 2019 when they beat Tottenham in all English final.
They’ve had mixed success against Italian clubs in recent years, having played an Italian team in every year of the Champions League since the 2017-18 season.
Below is a ranking of Liverpool’s top five victories over Italian teams in the club's history. We'll see if the Inter Milan-Liverpool Round of 16 battle makes the cut.
5. Liverpool 1-0 Napoli (2019)
Perhaps not the most iconic European night at Anfield, but nonetheless, a very important and underrated one. Liverpool welcomed Napoli for the last game of the 2018-19 group stage needing a win with a clean sheet, or a win by two clear goals to reach the knockouts.
Part of a dangerous group which saw French kingpins PSG, Napoli and the surprise package of Red Star Belgrade; Liverpool had faltered, losing away to all three teams.
Facing Napoli was no easy test, but Liverpool registered 23 shots on the night and dominated proceedings. Mohamed Salah's individual brilliance gave Liverpool the lead, after a dazzling run past Kalidou Koulibaly which saw him score from a tight angle.
Napoli didn't pose a real threat until injury time. When, in the dying minutes of the game, a cross found its way to Arkadiusz Milik five yards out and the Napoli forward looked poised to break Liverpool hearts. After a brilliant first touch, he fired straight at Alisson, who had rushed out to close the angle.
Not a vintage night at Anfield, but that moment from their Brazilian goalkeeper made sure of their qualification to the knockout rounds. That save is now considered priceless, given that Liverpool went on to lift the trophy some six months later.
4. Liverpool 2-1 Juventus (2005)
Facing off against a star-studded Juventus side, Liverpool welcomed the Italian giants to Anfield for the first leg of their 2004-05 Champions League quarterfinal series.
The likes of Zlatan Ibrahimovic, Fabio Cannavaro, Gianluigi Buffon, Pavel Nedved and Alessandro Del Piero were edged out in a 2-1 Liverpool victory that gave the Reds a slim advantage heading into the second leg.
Center back Sami Hyppia got Liverpool off to a flying start with a fine left-footed finish from a corner, and this was followed by a stunning strike from distance by Spaniard Luis Garcia 15 minutes later.
The Italian side pulled a goal back thanks to Cannavaro, then hit the post and had a seemingly legitimate goal ruled out for offside that these days would have surely been overturned by VAR.
Liverpool held on to advance after a 0-0 draw in the second leg. This series injected Liverpool with the belief to beat domestic rivals Chelsea in the semifinals and go all the way after one more epic showdown against another Italian side (more below).
3. Liverpool 5-2 AS Roma (2018)
This stands out as one of the most commanding semifinal first leg wins in Champions League history. AS Roma arrived at Anfield for the first leg of the 2017-18 semifinals following an iconic late comeback victory over FC Barcelona.
Liverpool’s Mohamed Salah was himself a former Roma player, but he showed them no remorse as he scored twice and assisted twice in a dazzling performance on the big stage.
The Reds powered to a 2-0 halftime lead, thanks to an unstoppable strike from outside the box from Salah. He then raced through on the counterattack to chip future Liverpool goalkeeper Alisson Becker, in a brilliant move.
By the 68th minute, Liverpool led 5-0 and fans were already booking their tickets for the final in Kyiv. Roma did then hit back with two late goals, but the damage was already done in a scintillating and breathtaking half-hour display.
2. Roma 1-1 Liverpool a.e.t. (1984)
Liverpool won their fourth European Cup in the 1983-84 season when they beat AS Roma on penalties at their home ground of Rome's Stadio Olimpico in a historic win for the English side.
Having won three European Cups in the seven years prior, including three in five seasons between 1976-1981, Liverpool were at the forefront of European football and arrived in Rome hoping to add another European title to their growing collection.
For Roma, it was their first appearance in a European Cup final.
Phil Neal gave the English side a dream start after only 14 minutes, but the home side hit back just before halftime thanks to a brilliant looping header from Roberto Pruzzo, a couple of minutes before half time.
Penalties were needed to separate the two teams, and Liverpool had a nightmare start as Steve Nicol fired over on the first attempt. Fortunately, Bruno Conti returned the favor to keep Liverpool in the shootout.
It was forward Francesco Graziani who, amazingly, also fired over before Alan Kennedy slotted home to secure a famous European Cup for the Reds.
1. Liverpool 3-3 AC Milan AET (2005)
What is regarded as one of the most famous ever Champions League finals saw Liverpool as sizable underdogs when they faced the mighty AC Milan in Istanbul in 2005.
Liverpool finished fifth in the Premier League that season, while Milan boasted one of the best starting XI’s in Champions League history, with most of the players going down in football history as legends of the game.
The Italian side quickly imposed itself on the game, scoring after just 50 seconds as Milan raced to a 3-0 lead at halftime.
Following one of Steven Gerrard’s most important goals as Liverpool captain, strikes from Vladimir Smicer and Xabi Alonso pulled Liverpool back from the brink to force extra time in a stunning turnaround.
After holding on for another half an hour, Liverpool goalkeeper Jerzy Dudek was the hero, saving twice from Ukrainian frontman Andriy Shevchenko from close range in the dying minutes of extra-time as penalties loomed.
With both sides missing penalties, Liverpool led 3-2 when Shevchenko stepped up for Milan. But his weak penalty was saved by Dudek to give Liverpool claimed its fifth European Cup in one of the most dramatic finals in football history.