Much of the focus this weekend fell on backup quarterbacks and how they would fare taking over the starting role.
Now that teams have their answers, the attention will turn to the rest of the offense — or in some cases the defense.
Here we look back at the biggest headlines from Week 3 and the impact they'll have heading into Week 4.
Daniel Jones awakens sleeping Giants
After being so harshly criticized for drafting the Duke star sixth overall in April, the team's brass had to be smiling Sunday. Jones threw for 336 yards and had four total touchdowns to help New York come back from an 18-point deficit at halftime and leave Tampa Bay with a 32-31 win to snap the team's winless streak. But is it too soon for fans to be so optimistic about the rookie?
Considering Eli Manning is 0-43 when trailing by 18 points or more as a starter, perhaps not. Jones tied for the second-largest comeback victory for a quarterback in his first career start since the 1970 merger and became just the second player since that year to record two rushing scores and two passing scores in his first career start.
The Giants return to New York for back-to-back games against the Redskins and Vikings before visiting the Patriots in Week 6.
Kyle Allen keeps Carolina afloat, but can he do it again?
The Panthers have already ruled Cam Newton out for Week 4 against the Texans and it's been reported he could miss more time before the team's Week 7 bye, though Allen proved to be dependable as he helped Carolina avoid an 0-3 start.
"What Cam needs right now is time and rest for his foot. We want him at 100 percent when he’s ready, so there’s no exact timetable for his return," coach Ron Rivera said in a release. "At this point, we’re going to go forward with Kyle (Allen) as our starter."
Allen threw four touchdown passes in Sunday's win at Arizona, while Newton has four total scoring passes in his last six starts and none in the past four. It also helped that the offense fired on all cylinders behind Greg Olsen and Christian McCaffrey, proving this season could maybe be saved after all.
Chargers may want to revisit Melvin Gordon holdout
Los Angeles dropped its second straight game Sunday and managed just 73 rushing yards in its 27-20 loss to Houston to fall to 12th in the NFL in net rushing yards, so the team's struggles could prompt an attempted reconciliation with the running back as he continues to hold out for a new contract.
After all, Gordon said in a video chat with his Instagram followers last week that he's "going to play somewhere" this season and that "it would be a waste of talent" if he didn't. Meanwhile, the Chargers have maintained they don't want to deal Gordon before he becomes a free agent in 2020.
A whopping eight teams remain unbeaten through three weeks
The Bills, Chiefs, Cowboys, Lions, Packers, Patriots, Rams and 49ers have yet to lose a game, and according to ESPN, it's just the second time in NFL history and first time since 1998 that's happened. It's also worth noting New England hasn't given up an offensive touchdown since the AFC championship last season and its point differential of plus-89 through Week 3 is tied for second-highest in NFL history.
On the other hand, the Bengals, Broncos, Dolphins, Jets and Steelers all dropped to a disastrous 0-3 start that almost definitively eliminates them from postseason contention. What's more interesting, though, is the fact that all five teams are in the AFC.
Is Antonio Brown really done with the NFL?
The receiver tweeted Sunday that he will "not be playing in the NFL anymore" and has since re-enrolled at Central Michigan University in the wake of his release from the Patriots on Friday. Brown, who previously attended the school from 2007-09 before declaring for the 2010 draft, is set to take classes online.
Classes are boomin’ at CMU! Former Chippewa star receiver & 7x NFL pro bowler Antonio Brown has reenrolled taking 4 classes online this fall. He posted his schedule on his Instagram story. pic.twitter.com/FUmRusfsZn
— Jason Lewis (@JasonLewis_TV) September 23, 2019
Brown was rumored to draw interest from other teams but his agent Drew Rosenhaus told ESPN those teams "want information regarding his legal situation and the NFL investigation," so any potential deal is not likely to happen until those issues are resolved.
In the meantime, Brown continues to deny the accusations of sexual misconduct as well as sexual assault and rape against him, all of which are still being investigated.