Broncos center Matt Paradis suffered a broken leg in Sunday's game against the Texans, according to Mike Klis of Denver's 9 News.
The fifth-year veteran had to be carted off the field late in the first half, and X-rays revealed a fractured fibula near the ankle.
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According to Klis, Paradis will miss a minimum of six weeks.
Paradis had not missed a game since entering the league in 2014. One of the Broncos' captains, Paradis is in negotiations to extend his rookie contract.
It's another big blow to Denver's O-line. The Broncos lost left guard Ron Leary to a torn Achilles in Week 6.