Quarterbacks and wide receivers have dominated headlines so far this 2022 NFL season, and the Eagles-Cardinals game in Week 5 will feature some of the most exciting players at both positions. These squads will square off in the desert in a battle of the birds, and we have the betting odds, tips, storylines, and predictions to get you ready for the vertical showcase.
Philadelphia's Jalen Hurts has inserted himself into early MVP discussions, clearly aided by the Eagles' offseason addition of wideout A.J. Brown. The Eagles are the last undefeated team standing -- something they have not been able to claim since 2004 when they started 7-0 and lost to the Patriots in the Super Bowl. The Philly faithful have high hopes for their Eagles, who have played well on both sides of the ball so far.
Meanwhile, fellow dual-threat QB Kyler Murray has powered Arizona to a pair of hard-fought wins over Vegas and Carolina. Murray has benefited greatly from Cards' offseason acquisition Marquise Brown, lessening the blow of All-Pro wideout DeAndre Hopkins' suspension (PEDs). But questions remain in Glendale, specifically about the Cardinals' defense.
WEEK 5 NFL PICKS: Against the Spread | Moneyline Picks
Will Philadelphia extend its torrid start to the 2022 season, or will Arizona continue on its track record of performing well in the early season under coach Kliff Kingsbury? Let's get you all the odds, narratives, stat trends, and predictions for this Week 5 aerial clash.
NFL WEEK 5 BETTING: Full list of odds for Week 5
Eagles at Cardinals odds for Week 5
Betting odds from Sports Interaction.
- Spread: Eagles -5.5 (-110) | Cardinals +5.5 (-110)
- Over/under: O 48.5 (-110) | U 49 (-110)
- Moneyline: Eagles -240 | Cardinals +199
According to BetQL's line movement analysis, the Eagles opened at -4, then crept to -4.5 and all the way to -6 before settling back to -5.5. The moneyline sat at -195 last week before shifting way up to the -240 area. The total opened at 48.5 and then took a little skip up to 49 after Week 4 concluded. BetQL has sharps slightly favoring the Eagles against the spread (51 percent of money, 58 percent of tickets) but has 68 percent of moneyline action on the Cardinals.
Take advantage of BetQL’s 3-day free trial and see all of our best bets across all sports, including college football, NFL and MLB!
WEEK 5 NFL DFS: Top sleepers and values
Eagles vs. Cardinals all-time series
The Eagles and Cardinals have met 121 different times, with the Cardinals leading the all-time series 60-56-5. Arizona has won six of its past eight meetings with Philadelphia, including a 33-26 win in Glendale back in December of 2020 when they last squared off. Murray and Hurts combined for 744 air yards and six passing TDs in that contest and added 92 ground yards and two rushing TDs.
Eagles vs. Cardinals: Trends to know
—Philadelphia is 3-1 against the spread this season. Arizona is 0-2 ATS as a home underdog.
—The Cardinals have surrendered 25.7 points per game this season. Hurts and the Eagles are 9-1 in the last 10 games in which they have posted 24 or more points.
—Since becoming the Cardinals head coach, Kliff Kingsbury is 12-3 in October.
Eagles at Cardinals: Three things to watch
Will Jalen Hurts continue to set the league on fire?
With respect to A.J. Brown, who's on pace for 1,700 yards in his debut season with the Eagles, Hurts has been the main catalyst for Philly's 4-0 start. The third-year QB has over 1,100 passing yards, 205 rushing yards, four TD passes, and four TD rushes. He has been accurate, with his 66.7 percent completion rate dwarfing his '21 rate of 61.3, and he leads the NFL in yards per pass attempt (9.1). Simply put, Hurts seems to be reading defenses and seeing the field lightyears better than he did in his first two campaigns. We don't expect this remarkable run to stop anytime soon. Arizona fields one of the worst scoring defenses in football, but the Cards should be able to contain Hurts on the ground. Through four games, Kingsbury's squad has allowed QBs to amass just 16 total rushing yards (second fewest in the NFL).
Does Arizona have enough defensively to stop powerhouse offenses like the Eagles?
The Cardinals took some big losses in the offseason, but edge rusher Chandler Jones might have been the biggest. Arizona ranks last in sacks per game (1.0) after averaging a solid 2.3 sacks per game in 2021. The result? The Cards rank 23rd in passing yards allowed, 24th in third-down percentage, and 25th in both red-zone defense and passing TDs allowed. Not great, Bob!
Can Kyler Murray and Hollywood Brown make a statement against Philly's D?
Murray and Brown have thrived since the Oklahoma college teammates reunited following an offseason trade with Baltimore. With lead Cardinals receiver DeAndre Hopkins suspended until Week 7, Brown has caught 30 passes and two TDs in his first four games. His highlight game of the young season came in a Week 3 loss to the division-rival Rams when Hollywood caught 14-of-17 targets for 140 yards. He and Murray will need to have extremely productive games against Philly, the third-best yardage defense in the NFL and No. 1 D in net yards allowed per pass as well as takeaways.
Eagles at Cardinals: Stat that matters
+155. That's Arizona's run yards differential in wins. In their two victories, the Cardinals rushed for 143 and 132 yards, while holding opposing teams to rushing totals of 80 and 40. In Arizona's two losses, the Cards totaled 103 and 70 rushing yards while allowing opponents to accrue rushing totals of 128 and 100 (-55 differential). The Eagles, led by Hurts and lead running back Miles Sanders, are first in rushing TDs (10) and fifth in rushing yards (661) on the young season.
Eagles at Cardinals: Prediction
The Cardinals have some things going for them, but they simply don't have enough defensive firepower to slow down Hurts, Brown, Sanders, wideout DeVonta Smith, and tight end Dallas Goedert. Their weaknesses on the defensive line are obvious and put too much pressure on Budda Baker and the secondary. Couple that with the fact that Philly's defense has been one of the better units in football, and you have the recipe for another ugly loss, similar to what Arizona experienced in Week 1 against the Chiefs (44-21). The Eagles are flying too high right now, and the Cardinals are barely in the same stratosphere.
UPDATED PREDICTION: Eagles 34, Cardinals 23. Philadelphia wins and covers (-5.5), and the game easily goes OVER (48.5) in garbage time.
