It may be hard to believe, but Week 6 of the NFL season has arrived. We have entered the dreaded bye-week season, which means a narrower slate each week, but plenty of betting goodness can be found on this weekend's docket, including countless fun and potentially lucrative prop bets.
Player props, game props, and same-game parlays have become massively popular through the years, and with slates like Week 6 that feature a handful of uneven matchups (and thus large point spreads), it's easy to see why. Props are not only more fun to follow throughout the game, but they also rarely produce as many infamous "bad beats" as standard moneyline, spread, and over/under bets.
If you do your research and follow the trends (while also avoiding injury), you will usually come out with more winners than losers in the prop-betting market. The concept of "any given Sunday" holds less weight, as stud players tend to put up their numbers in plus-matchups, win or lose.
Every Thursday, we scour Caesars Sportsbook to pinpoint one potentially profitable prop for each NFL game of the upcoming slate. It could be a player or team prop that we find the most interesting, most lucrative, or both. These prop wagers can involve offense, defense, special teams, or general scoring, but they always stand out as the most intriguing and/or yielding the most value to bettors.
Let’s check out our favorite Week 6 props for every game and make some money in what should be another fun week of NFL action.
MORE WEEK 6 NFL BETTING: Odds, lines, spreads | Best bets
Best NFL prop bets for every Week 6 game
All prop bets are from Caesars Sportsbook/William Hill
Commanders at Bears: Terry McLaurin OVER 54.5 receiving yards (-137)
This one is partly about willing TMC back into meaningful existence. Something's gotta give for the skilled receiver, who just hasn't found a way to jell with first-year Commanders QB Carson Wentz. Look, McLaurin is getting open and drawing a decent amount of targets (6.6 per game), and we all know how skilled he can be in the open field. With rookie receiver Jahan Dotson (hamstring) and veteran tight end Logan Thomas (calf) both set to miss this Thursday Night Football tilt, here's betting Terry gets scary again just in time for Halloween season. The Bears let Justin Jefferson run wild against them last weekend for12 catches and 154 yards. TMC is no JJ, but he's good enough to rack up 55-plus air yards.
Buccaneers at Steelers: Mike Evans (-109) and/or Chris Godwin (+119) to score a TD
I included both Bucs wideouts because both see good volume as the last of Brady's stud receivers, and both should be able to feast against Pittsburgh. Stefon Diggs and Gabe Davis combined for 273 yards and three TDs last weekend against the Steelers, likely leaving safety Minkah Fitzpatrick wondering what happened to the pieces around him. Pittsburgh won't be competent defensively until edge rusher T.J. Watt returns from his pec injury and until rookie QB Kenny Pickett can control the ball and clock more effectively. Brady and his two favorite targets should have themselves a day.
Packers vs. Jets: Aaron Rodgers OVER 245.5 passing yards (-109)
Rodgers gets a generous over/under here after the Jets held Skylar Thompson and the Dolphins to 166 passing yards, but the gap between Thompson and Rodgers is like the gap between Steak-umms and filet mignon. Consider the fact that Gang Green allowed 250-plus passing yards in each of their previous four games, and that includes a Mitchell Trubisky/Kenny Pickett game. Rogers' OVER 245.5 yards at Lambeau is the prop bet of the week.
WEEK 6 NFL PICKS: Against the Spread | Moneyline Picks
Vikings at Dolphins: Adam Thielen to score a TD (+165)
Everyone thought I was going Justin Jefferson here, but JJ is such a stud he gets negative odds on TD props. With Miami likely to double the All-Pro third-year receiver, here's betting Thielen comes down with his second score of the season in what should be a sunny day for Vikings fans.
Ravens at Giants: Ravens -6.5 alternate line (+102)
We love toggling the line until we get to plus odds, especially in a game featuring Lamar Jackson vs. Daniel Jones. We get it -- Brian Daboll has led the Giants to a 4-1 start. He's a genius, and Saquon Barkley is back. But the way to beat this Ravens is through the air, and Jones has always been prone to turnovers. Baltimore ranks No. 1 in the league in both interceptions (8) and total takeaways (11). It could be a dark day in the Meadowlands.
WEEK 6 NFL PICKS ADVICE: Pick'em & Survivor Pools
Patriots at Browns: David Njoku to score a TD (+265, DraftKings)
We couldn't find any props for this one on Caesars, so to DraftKings we headed. Bill Belichick and the Patriots just rolled the Lions 29-0, completely taking out Detroit's last remaining uninjured weapon in T.J. Hockenson. Now BB and his perennially underrated defense will shift their sights to NFL rushing leader Nick Chubb and probably stick emerging stud defensive back Jack Jones on Amari Cooper. That leaves plenty of red-zone opportunities for Njoku, who could very well score the sixth TE touchdown on the Patriots in six games. Only the Raiders have surrendered more TDs to TEs than New England, while the Pats lead the NFL with zero rushing TDs allowed. This is a no-brainer at +230.
Bengals at Saints: Evan McPherson OVER 1.5 field goals (-160)
The Saints have been banged up but are surviving off the old-school strategy of strong defense and a relentless run game. Meanwhile, the Bengals have looked horrendous on offense, with Joe Burrow struggling in a constantly collapsing pocket his supposedly fortified offensive line should be protecting. I don't doubt that Cincy will mount a few drives in this one, but New Orleans ranks second in both third-down and red-zone defense. The second-best kicker in the league could be busy in the bayou this weekend.
49ers at Falcons: Jeff Wilson Jr. to score a TD (+115)
In a game pitting Jimmy G's yuck vs. Marcus Mariota's poo, expect a healthy amount of San Francisco's go-to: rushing attempts. Wilson Jr. has filled in admirably for Elijah Mitchell (sprained MCL), scoring in each of the 49ers' past two games. The Falcons have allowed five rushing scores and surrendered two total TDs to Leonard Fournette last weekend in a ref-aided loss to the Bucs. JWJ is safe in what should be an ugly game, provided Tevin Coleman and Tyrion Davis-Price don't yoke all his red-zone opportunities.
Jaguars at Colts: Colts UNDER 20.5 points (-115)
Sometimes you just have to follow the trends. With little to no prop bets available for this game as of publishing, we're going with the Colts to continue struggling to score points. Indy has scored 69 total points all season and has yet to eclipse 20 points in a game. Matt Ryan looks washed, and the Colts rank 24th in third-down conversion percentage and 28th in red-zone TD percentage. The Jaguars, meanwhile, quietly have the fourth-best scoring defense in the NFL. Matty Ice stays cold.
Cardinals at Seahawks: Zach Ertz to score a TD (+180)
The Cardinals have missed suspended All-Pro receiver DeAndre Hopkins all season, but they really miss him now. Starting running back James Conner aggravated his rib injury in Arizona's tough loss to the Eagles last weekend, which is another big hit to Kliff Kingsbury's offense. Kyler Murray has consistently looked Ertz's way all season, and the Seahawks have struggled to defend tight ends, allowing 404 yards (second most) and four TDs (third most). Ertz should be able to collect his third TD of the season against a Seahawks squad that has allowed 38.8 points per game over the past four weeks.
Panthers at Rams: Christian McCaffrey OVER 59.5 rushing yards (-111)
Matt Rhule finally got the boot from Carolina, and Steve Wilks will take over as the Panthers' interim head coach. That should delight Panthers' fans and fantasy owners of McCaffrey, as Wilks has always coached teams that heavily utilized the run game. The Rams defense is a shell of what it once was, and Matthew Stafford has struggled to control the clock all season. Expect CMC to rack up at least 75 yards on the ground.
Chiefs vs. Bills: Patrick Mahomes OVER 2.5 passing TDs (+126)
I have the Bills winning this game, but I don't think Mahomes and the Chiefs will go out without a fight at Arrowhead Stadium. Normally, we would shy away from a three-TD prop, but Mahomes elevates to a different level against high-flying squads and AFC rivals. He and stud tight end Travis Kelce just connected for a Monday Night Football-record four TDs, and Kansas City will be launching the ball all afternoon in Buffalo's biggest defensive test of the young season. The plus-odds are worth it in this case. Andy Reid won't put the ball in RB Clyde Edwards-Helaire's hands in the big moments.
Cowboys at Eagles: Jalen Hurts OVER 1.5 passing TDs (+114)
Two weeks ago, I posted on Twitter that Jalen Hurts was playing MVP-caliber football and the Eagles are bona fide Super Bowl contenders. One person commented that Philadelphia is not a contender and that Hurts is garbage. That user has since deleted his comment and sources tell me he's gone into a Twitter protection program. Newsflash, people: Hurts is really, really good and he has myriad weapons around him. At home in one of Philly's biggest games of the regular season — in prime time, no less — he should toss at least two scores.
Broncos at Chargers: Mixed SGP — Chargers' moneyline, Chargers' 1st quarter ML (three-way), OVER 45.5 points (+310, DraftKings)
It seems a bit too early for the books to give us player props for this one, maybe due to Russell Wilson (shoulder) and Keenan Allen (hamstring) both ailing. Thus, we'll cap off our 13-prop column with a fun one from DraftKings. This same-game parlay mixer specifies that the Chargers must win the first quarter and the game in addition to the game finishing with a combined score of OVER 45.5 points (alternate total). We like it! Wilson should play, and we expect he and Justin Herbert to be slinging the ball a bunch in a divisional game that both the 2-3 Broncos and 3-2 Bolts likely view as a must-win. Los Angeles is at home, so we'll give the better overall home squad the benefit of our ML pick for the first frame and final score. A total of 45.5 seems quite attainable in a prime-time game with both defenses banged up. Hopefully, our last and most lucrative bet caps off a strong week of prop-betting goodness!
