Nine of 10 Big 12 teams won their season opener, and the conference has a chance to make a few statements in Week 2.
That starts with No. 9 Iowa State, which will try to break a four-game losing streak against No. 10 Iowa in their rivalry series. The Cyclones are getting the ESPN GameDay treatment, and the atmosphere at Jack Trice Stadium should be off the charts.
No. 15 Texas travels to Arkansas to renew an old-school rivalry, and the Longhorns are looking to go 2-0 under first-year coach Steve Sarkisian. The Razorbacks and Longhorns have not played since 2014 and it is only Texas' second trip to Fayetteville since the Razorbacks left the Longhorns and the rest of the Southwest Conference in 1992.
BENDER: Picks against the spread for Top 25 games | Week 1 takeaways, from Bryce Young to Clemson and more
Those are the highlights on a schedule where five teams in the conference play FCS opponents.
MORE: Watch Big 12 college football games on ESPN+
Here are the Week 2 odds in the Big 12:
Big 12 odds for Week 2
Here are the latest Big 12 odds, including point spreads, money lines and over-under totals for every game, according to FanDuel.com.
Big 12 point spreads for Week 2
| Game | Spread |
| Kansas at No. 17 Coastal Carolina (Friday) | CC -22.5 |
| Tulsa at Oklahoma State | OKST -13.5 |
| Cal at TCU | TCU -9.5 |
| No. 10 Iowa at No. 9 Iowa State | ISU -4.5 |
| No. 15 Texas at Arkansas | TEX -6.5 |
Big 12 money lines for Week 2
| Game | Moneyline |
| Kansas at No. 17 Coastal Carolina (Friday) | KU +1260 |
| Tulsa at Oklahoma State | OKST -600 |
| Cal at TCU | TCU -430 |
| No. 10 Iowa at No. 9 Iowa State | ISU -205 |
| No. 15 Texas at Arkansas | TEX -260 |
Big 12 over/unders for Week 2
| Game | Over/Under |
| Kansas at No. 17 Coastal Carolina (Friday) | 52.5 |
| Tulsa at Oklahoma State | 52.5 |
| Cal at TCU | 48.5 |
| No. 10 Iowa at No. 9 Iowa State | 44.5 |
| No. 15 Texas at Arkansas | 57.5 |
Big 12 best bets for Week 2
Kansas (+25.5) at No. 17 Coastal Carolina
Seriously? The Jayhawks did break a 19-game win streak last week, and first-year coach Lance Leipold offers optimism for the future. Coastal Carolina presents multiple problems on offense, and the Chanticleers have beat Kansas the last two seasons. That average margin of victory, however, was just 10 points per game. Transfer quarterback Jason Bean makes a few plays in the passing game that compensate for a stagnant running game. The Jayhawks manage a cover on the road.
No. 10 Iowa (+4.5) at No. 9 Iowa State
We still like the Cyclones to win S/U, but this is a tough pick knowing that the Hawkeyes have won the last four meetings and looked solid on both sides in a season-opening victory against Indiana. Iowa State looked shaky in their opener, but the core of Brock Purdy, Breece Hall, Charlie Kolar and Mike Rose returned for this game. For those interested in the under (44.5), the last two meetings were defensive slugfests. Iowa won 18-17 in 2019 and 13-3 in 2018.
No. 15 Texas (-6.5) at Arkansas
The Longhorns covered the spread at home against G5 upstart Louisiana in Week 1. Can they do it on the road against an old Southwest Conference rival? The Razorbacks have made a living off the underdog card under Sam Pittman, and they are 7-3 ATS as an underdog with the second-year coach. Sarkisian, however, knows Arkansas from his time as Alabama's offensive coordinator. This is another chance for Bijan Robinson to creep into the Heisman conversation. Texas covers again.
MORE WEEK 2 ODDS: SEC odds, lines and point spreads
