Giovani dos Santos and his brother, Jonathan, are both making their return to the starting lineup for Mexico as El Tri face Costa Rica in a World Cup qualification match Tuesday night.
While Mexico already is qualified, Costa Rica needs a result to lock up its position in Russia.
Javier "Chicharito" Hernandez and Jesus "Tecatito" Corona drop to the bench in a decision coach Juan Carlos Osorio surely took in part because his team's place in next summer's tournament already is secure.
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While Jurgen Damm, who started Mexico's 1-0 victory Friday over Panama, is on the bench he is unlikely to see action in Tuesday's game after taking a knock in training.
Mexico starting XI: Guillermo Ochoa; Edson Alvarez, Jair Pereira, Hector Moreno, Jesus Gallardo; Diego Reyes, Jonathan dos Santos, Andres Guardado; Giovani dos Santos, Raul Jimenez, Hirving Lozano
Bench: Jesus Corona, Rodolfo Cota, Javier "Chicharito" Hernandez, Jesus "Tecatito" Corona, Raul Lopez, Hugo Ayala, Cesar Montes, Orbelin Pineda, Javier Aquino, Jurgen Damm, Carlos Vela
Costa Rica starting XI: Keylor Navas; Cristian Gamboa, Johnny Acosta, Kendall Waston, Francisco Calvo, Bryan Oviedo; David Guzman, Celso Borges; Christian Bolanos, Bryan Ruiz; Marco Urena