Reigning champions Manchester City will face local rivals Manchester United in the fourth round of the Women's FA Cup.
The Citizens, who claimed their second title last May with a 3-0 win over West Ham, will make the short journey to Leigh to visit Casey Stoney's side, with all ties to take place on Sunday, January 26.
The pair have met twice already this season, with City 1-0 winners on the opening day at the Etihad, but United getting their revenge with a 2-0 victory in the Continental Cup in October.
West Ham will be looking to go one better this season, but face a tough test themselves in the next round against current Women's Super League champions, and leaders, Arsenal.
Fellow WSL giants Chelsea also have a London derby to look forward to, with the Blues set to make the trip to Championship side Charlton Athletic. While Chelsea are chasing down another league title, Charlton have struggled this season and currently sit bottom of the second tier.
Elsewhere, Everton have also drawn a side from the division below, the Toffees hosting London Bees, Tottenham will be paid a visit by fourth-tier Barnsley and Birmingham travel to Sheffield United in a tie that has the potential to produce a giant killing. The WSL outfit are battling relegation this season, while the Blades are flying high in second in the Championship.
The same can be said of Brighton's draw away to Aston Villa, the team top of the second division, and Durham's trip to Bristol City, though the Robins did pick up a huge win at Man Utd on Sunday.
The team bottom of the WSL, Liverpool, will face Blackburn Rovers, who they beat 6-0 in the Continental Cup earlier this season.
Billericay Town and Actonians are two of the lowest ranked sides left in the draw, with their third round tie still to be played after it was postponed on Sunday, January 5. The winner of that clash will face second-tier Lewes in the next round.
Sunderland's trip to Fylde was also called off, leaving Watford without a confirmed opponent for now.
Draw in full:
West Ham vs Arsenal
Man United vs Man City
Lewes vs Billericay Town or Actonians
Charlton vs Chelsea
Everton vs London Bees
Burnley vs Leicester City
Sheffield United vs Birmingham City
London City Lionesses vs Reading
Bristol City vs Durham
Tottenham vs Barnsley
Huddersfield vs Ipswich
Southampton FC Women vs Coventry United
Southampton Women FC vs Crystal Palace
Fylde or Sunderland vs Watford
Liverpool vs Blackburn
Aston Villa vs Brighton
