Virgil van Dijk and Dejan Lovren are paired together for the first time as Liverpool host Tottenham on Sunday.
The £75 million signing was on the bench for the 3-0 victory at Huddersfield Town, but partners the Croatian in the heart of defence at Anfield.
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Van Dijk’s three other starts for the club have been alongside Joel Matip, who switches to the bench.
Trent Alexander-Arnold replaces Joe Gomez at right-back, who misses out through injury.
Jurgen Klopp's side are otherwise unchanged in midfield and attack.
Last time out, they beat Huddersfield 3-0, with Emre Can, Roberto Firmino and Mohamed Salah on target.
Liverpool starting XI: Karius; Alexander-Arnold, Lovren, Van Dijk, Robertson; Henderson, Can, Milner; Salah, Mane, Firmino
Subs: Mignolet, Matip, Moreno, Wijnaldum, Chamberlain, Ings, Solanke
