Serena Williams and Maria Sharapova face a mouthwatering first-round tie at the US Open, while Australian second seed Ashleigh Barty could face the legendary American in a quarter-final match-up.
Williams will be a heavy favourite given her 19-2 head-to-head record over Sharapova, though it will be the first time the rivals have gone up against each other in New York.
The pair last met on court in the 2016 Australian Open quarter-finals, where Williams was victorious, with a last-16 tie at the 2018 French Open a non-starter due to the American suffering a pectoral injury.
Sharapova has not defeated her illustrious foe in a match since 2004 and faces a monumental challenge against Williams, who was beaten in the final 12 months ago by Naomi Osaka.
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Second seed Ashleigh Barty, who made a major breakthrough at Roland Garros, opens up against Zarina Diyas and faces a potential last-eight meeting with Williams.
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There are four more Australian women in the main draw, with Daria Gavrilova to meet Fiona Ferro, veteran Sam Stosur to face Ekaterina Alexandrova, Ajla Tomljanovic to take on Marie Bouzkova and Astra Sharma to play Magda Linette.
Top seed Osaka's bid to defend her title at Flushing Meadows begins against Anna Blinkova, while Kiki Bertens is a potential quarter-final opponent.
Karolina Pliskova (3) and Simona Halep (4) each face qualifiers in round one, the latter on a potential last-eight collision course with Petra Kvitova (6).
Defending men's champion Novak Djokovic, aiming to win a third slam of 2019, faces the unheralded Roberto Carballes Baena first but could be set for a daunting run at Flushing Meadows.
The defending champion draws Carballes Baena in R1...
— US Open Tennis (@usopen) August 22, 2019
Projected QF: (5) Medvedev #USOpen | @DjokerNole pic.twitter.com/HyboakYllY
Fifth seed Daniil Medvedev, a man in form having reached the finals in Washington and Montreal while also winning the title in Cincinnati, is Djokovic's projected quarter-final opponent, while Roger Federer may stand in the way in the semis.
Five-time champion Federer faces a qualifier first up, while on the other side of the draw Rafael Nadal has a tricky first-round tie with Australian John Millman – who upset Federer in round four a year ago.
Dominic Thiem, Stefanos Tsitsipas and Alexander Zverev could all prove potential road blocks for Nadal in the latter stages.
Controversial Australian Nick Kyrgios opens his campaign against American Steve Johnson. while Alex de Minaur faces Frenchman Pierre Hugues Herbert in the opening round.
Jordan Thompson will meet Joao Sousa, young gun Alexei Popyrin plays Federico Delbonis while Thanasi Kokkinakis rounds out the Aussie men's contingent and will face a yet to be determined qualifier.