Marin Cilic claimed a much-needed win in the Citi Open second round, while Jo-Wilfried Tsonga caused an upset on Tuesday.
Cilic, yet to hit top form this year, battled past Marius Copil 7-6 (7-4) 7-6 (7-4) to reach the last 16 at the ATP 500 event in Washington.
The Croatian sixth seed and 2014 US Open champion improved to just a 12-10 win-loss record this year thanks to the hard-fought victory.
The only seed to fall on Tuesday was Karen Khachanov, who went down to Tsonga.
Tsonga served 13 aces in a 6-4 2-6 7-5 victory over Khachanov, the second seed losing to the Frenchman for the third time in as many meetings.
Upset Alert
— US Open Tennis (@usopen) July 31, 2019
Jo-Wilfried Tsonga upsets No. 2 seed @karenkhachanov and advances to the quarterfinals at @CitiOpen #USOpenSeries | @tsonga7 pic.twitter.com/1Zgpg8KhWn
Daniil Medvedev, Kyle Edmund and Frances Tiafoe joined Cilic and Tsonga in the third round.
Medvedev eased past wildcard Bjorn Fratangelo 6-3 6-4, Edmund crushed Lloyd Harris 6-1 6-4 and Tiafoe was too good for Alexander Bublik 6-1 7-6 (7-5).
Meanwhile, Jack Sock's wait for a first singles win of the year continues after losing 7-5 6-3 to Jordan Thompson in the first round.
Nick Kyrgios sent down 15 aces on his way to a 7-5 6-4 win over qualifier Thai-Son Kwiatkowski, Reilly Opelka edged Christopher Eubanks 6-4 7-6 (7-3) and Yoshihito Nishioka was untroubled by Dan Evans in a 6-4 6-1 victory.
The master of tricks prevails in two, 7-5, 6-4@NickKyrgios // #CO19 pic.twitter.com/GP6S6Uklcd
— Citi Open (@CitiOpen) July 31, 2019
Peter Gojowczyk and Miomir Kecmanovic also advanced after wins over Andrey Rublev and Alexei Popyrin respectively.