Willi Heinz is set to start in place of Ben Youngs in one of five England changes for Saturday's Calcutta Cup clash with Scotland.
Eddie Jones has opted to make several alterations after the Rugby World Cup runners-up were beaten 24-17 by France in their Six Nations opener last week.
Heinz comes in at scrum-half for just his fourth international start with Youngs dropping to the bench, while Jonathan Joseph will start at outside centre in place of the injured Manu Tuilagi at Murrayfield.
Mako Vunipola and George Kruis return at prop and lock respectively, and Lewis Ludlam is in at flanker in place of Courtney Lawes.
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Joe Marler is omitted from the squad altogether, with Ellis Genge among the replacements.
Saracens back-rower Ben Earl is in line to make his England debut after being named among the substitutes.
Eddie Jones has named his side to face Scotland in the second round of the #GuinnessSixNations #WearTheRose @O2sports pic.twitter.com/6JEbUdCu8H
— England Rugby (@EnglandRugby) February 6, 2020
England team to face Scotland:
George Furbank; Jonny May, Jonathan Joseph, Owen Farrell, Elliot Daly; George Ford, Willi Heinz; Mako Vunipola, Jamie George, Kyle Sinckler; Maro Itoje, George Kruis; Lewis Ludlam, Sam Underhill, Tom Curry.
Replacements: Tom Dunn, Ellis Genge, Will Stuart, Joe Launchbury, Courtney Lawes, Ben Earl, Ben Youngs, Ollie Devoto.