Josh Scowen gave his side the lead six minutes after the break, pouncing on a poor clearance to tuck home, before Sam Wood doubled the lead 20 minutes later with a close-range header.
The result keeps Gareth Ainsworth’s side two points clear at the top of the table, as Bury bounced back from their 3-2 defeat at Wimbledon last week by trouncing Portsmouth 3-0 at Gigg Lane
Surprisingly, bottom club Tranmere Rovers are the only side to have beaten Wycombe so far this season, but they slumped to a 2-0 defeat at Oxford United in a meeting of the Football League’s bottom two sides.
The visitors fell behind after 28 minutes courtesy of Peterborough loanee Tyrone Barnett’s strike, before Danny Rose’s cross found Alfie Potter 19 minutes from time, who finished with aplomb, leaving new Rovers manager Micky Adams, who watched from the stands at the Kassam Stadium, with much to ponder.
York City also appointed a new boss this week, with Russ Wilcox taking over from the outgoing Nigel Worthington.
However, his arrival could not immediately change the fortunes at Bootham Crescent, as they went down to a 1-0 defeat at home to Shrewsbury Town.
A difficult afternoon saw Ryan Jarvis shown a straight red for a challenge on Nathaniel Knight-Percival and the visitors took advantage, securing the win three minutes from time courtesy of a drive from James Collins.
Burton Albion’s promotion bid suffered another setback with a 2-0 defeat at home to Morecambe but Plymouth Argyle continued their play-off bid by ending Carlisle United’s three-match winning run with a 1-0 triumph.
Fourth-placed Luton Town kept in touch with the automatic promotion spots with a 2-1 victory at struggling Hartlepool United.
Elsewhere, a Terry Gornell brace helped Cheltenham Town end their seven-game unbeaten run with a 3-2 win over Northampton Town, leaving them level on points with ninth-placed Newport County, who beat Dagenham and Redbridge 1-0 with a late strike from Chris Zebroski.
In the day’s other games, Stevenage beat Accrington Stanley 2-1, Southend United were held 1-1 by Exeter City, while Cambridge United drew 0-0 at Mansfield Town.