France fly-half Camille Lopez has been ruled out of his team's Six Nations clash against England due to a knee injury.
Lopez suffered the injury during France's 29-0 win over Italy on Sunday, and he will miss the meeting with England at Twickenham.
Maxime Machenaud, 26, will replace Lopez in the squad for Saturday's clash, the French Rugby Federation announced.
France sit fourth in the Six Nations table, two points behind England, Ireland and Wales as the tournament nears a thrilling conclusion.
Philippe Saint-Andre's men still have slim hopes of winning the title, but need a win and for Ireland and Wales to lose to Scotland and Italy respectively.