The Jacksonville Jaguars said four players were detained by police after an incident at a London bar.
Jacksonville released a statement, confirming earlier reports that the quartet had been detained "over restitution of a bill" on Saturday.
The Jaguars did not reveal who was involved ahead of Sunday's clash with NFL Super Bowl champions the Philadelphia Eagles at Wembley Stadium.
"We are aware that four of our players were detained over restitution of a bill," the Jaguars said in a statement acquired by NFL.com.
"The matter is being resolved and the players are with the team. Any discipline will be handled internally."
The Jaguars (3-3) will be looking to arrest a three-game losing streak when they face the Eagles (3-4).