The Rockets have announced star guard James Harden suffered a grade-two hamstring strain on Monday (AEDT) against the Lakers, and will be re-evaluated in two weeks.
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Harden, who had 40 points and 11 assists, was injured with less than a minute to play in regulation, limping and dragging his left leg after a drive to the basket.
He had only missed two regular-season games over the previous three seasons combined and has played in all 35 games this season.
Houston (26-9) ended its five-game losing streak against the Lakers, but they will have to find offence elsewhere with the NBA's leading scorer out at least two weeks.
Harden has scored at least 20 points in every game this season.
Since the 1963-64 season, only Harden, Kareem Abdul-Jabbar and Wilt Chamberlain have scored at least 20 points their teams' first 35 games, the Houston Chronicle noted.