If Diego Simeone is searching for ways to invigorate Atletico Madrid following their defeat at Bayer Leverkusen on Tuesday, the chance to end Real Madrid's unbeaten start to the season and move within striking distance of the top of the La Liga table should help.
Atleti were on course for a useful fourth point from two games in their Champions League campaign until the 84th minute at Leverkusen, when Robert Andrich put the Bundesliga side ahead three minutes before Moussa Diaby sealed their victory.
Madrid also left it late, Federico Valverde making the breakthrough with 10 minutes remaining at home to RB Leipzig. Marco Asensio added a second in added time.
Keen to see how the Spanish heavyweights clash for the first time in the Liga season? Here's what you need to know.
MORE: Real Madrid vs. RB Leipzig result: Valverde, Asensio rescue La Liga champions who remain perfect
What time is Atletico Madrid vs. Real Madrid?
Atletico Madrid play host to Real Madrid at the Metropolitano Stadium in Madrid, Spain. It kicks off at 8 p.m. BST on Sunday, September 18.
| UK | USA | Canada | Australia | |
| Date | Sunday, Sept. 18 | Sunday, Sept. 18 | Sunday, Sept. 18 | Monday, Sept. 19 |
| Time | 20:00 BST | 15:00 ET | 15:00 ET | 05:00 AEST |
How to watch Atletico Madrid vs. Real Madrid
| UK | USA | Canada | Australia | |
| TV channel | ITV 4, Premier Sports 2 | - | TSN5 | - |
| Streaming | Premier Player HD, LaLigaTV, ITV Hub | ESPN+ | TSN App, TSN.ca | Optus Sport |
UK: ITV 4 and Premier Sports 2 are broadcasting the action, as are Premier Player HD, LaLigaTV and the ITV Hub for streamers.
USA: ESPN will carry the Madrid derby live.
Canada: The match will be shown on TSN and the TSN app and website.
Australia: Fans in Australia can stream matches live and on demand on Optus Sport.
Atletico Madrid vs. Real Madrid predicted lineups
Goalkeeper Jan Oblak failed a fitness test before Atleti's defeat at Leverkusen, having been forced off late in their league match against Real Sociedad following a collision with teammate Reinildo Mandava.
Defenders Jose Maria Gimenez (back) and Stefan Savic (thigh) have also been out. Left-back Sergio Reguilon, who is on loan from Tottenham Hotspur, has a groin injury.
Atletico Madrid predicted lineup (3-5-2): Grbic (GK) — Witsel, Felipe, Hermoso — Molina, Llorente, Koke, Saul, Reinildo— Morata, Felix
Forward Karim Benzema scored three goals and set up another in his side's opening four league fixtures before being ruled out by a muscular problem that has left Vinicius Junior as Madrid's key goal threat.
Wideman Lucas Vazquez is sidelined until October with a thigh problem and defender Eder Militao has a hamstring issue, although Carlo Ancelotti said the Brazilian should be fit to play a part in the game.
Real Madrid predicted lineup (4-3-3): Courtois (GK) — Carvajal, Rudiger, Alaba, Nacho — Modric, Tchouameni, Camavinga — Valverde, Rodrygo, Vinicius
MORE: Karim Benzema injury update: How many matches will Real Madrid captain miss?
Atletico Madrid vs. Real Madrid betting odds
Atleti had failed to beat Madrid in 12 attempts in domestic competition before their 1-0 home victory in May, by which time their opponents had already won La Liga at a canter.
That could mean Simeone will be content to see his side close the shutters and target a point against visitors in flawless form. Only one of the past 13 meetings between these teams in league and Spanish cup competitions has produced more than two goals.
| UK (Sky Bet) | USA (DraftKings) | Canada (Sports Interaction) | |
| Atletico Madrid Win | 21/10 | +205 | 3.03 |
| Draw | 12/5 | +240 | 3.37 |
| Real Madrid Win | 5/4 | +120 | 2.26 |
| Over 2.5 Goals | 5/6 | -110 | 1.89 |
| Both Teams to Score | 4/6 | -145 | 1.66 |
