Adelaide and Carlton will see the opening of the inaugural Gather Round that has descended on South Australia.
The Crows and Blues have welcomed back some of their stars, including Sam Walsh, who has yet to play a game in 2023.
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For Fremantle and Gold Coast, both clubs might look at making some bold calls given their poor start to the season.
Jye Amiss could make some room in the senior side after another quiet performance in round four while Nathan O'Driscoll failed to impact the game and was subbed out half way through the third quarter.
Joel Jeffrey slotted one goal from five touches as Mabior Chol pushes his case in the VFL.
Richmond will be forced into at least three changes for their clash with Sydney as Toby Nankervis, Jack Graham and Tom Lynch are out injured.
Whereas the Swans will also have to fill the absence of the McCartin brothers (concussion) and Lance Franklin.
INJURY UPDATE: Lance Franklin to miss clash with Richmond.
— Sydney Swans (@sydneyswans) April 11, 2023
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As for Brisbane, it's hard to change up a winning combination that dominated Collingwood.
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However, Jaxon Prior could be the unlucky one that makes room for the returning Daniel Rich, who is coming back from injury and expected to be ready to go.
North Melbourne also have some selection calls to make and Charlie Comben might be one of them.
Comben has been persisted with but struggled in the Good Friday clash, while Callum Coleman-Jones has been waiting in the wings.
George Wardlaw has impressed in the VFL and might force out Kayne Turner.
Melbourne are unlikely to make a change unless Ben Brown and James Harmes are fit, which could cause a selection conundrum.
Essendon, however, could look at reshuffling their forward line.
Harrison Jones was kept goalless for the fourth time this season as Patrick Voss continues to impress in the VFL.
Ken Hinkley's week at the selection table should be made easier after their stirring win over Sydney.
Despite the form of Mitch Georgiades in the twos and the potential return of Riley Bonner and Orazio Fantasia, it's unlikely Port Adelaide will make any changes.
Similar story for the Western Bulldogs, but will need to replace Alex Keath at least.
Robbie McComb and Arthur Jones were quiet in last week's win over Richmond and could face the chopping block as Cody Weightman is set to return.
Geelong's Mark O'Connor could be pushed back into the sub role as Sam de Koning is expected to be available after dealing with concussion.
Brady Hough and Elijah Hewett were both very quiet in the big loss to the Demons and might make room for Dom Sheed and Jack Petruccelle.
Looking at the Giants, there are a few names that could be seen as unlucky heading into round five.
Conor Stone, Adam Kennedy and Jake Riccardi may all find themselves in the twos this week.
The trio failed to perform from substantial game time and coach Adam Kingsley could unveil two debutants.
Aaron Cadman and Josh Fahey have been forced to wait for their turn, while Xavier O'Halloran returned successfully from his quad injury.
After being smashed on Easter Monday by the Cats, Hawthorn are bound to make some changes as performances like that aren't accepted at AFL level.
Tyler Brockman was subbed out of the game, as Jack Scrimshaw and Conor Nash struggled.
Sam Butler and Max Lynch were impressive in the reserves as was Lachie Bramble and Ned Long.
The conclusion of Gather Round ends with St Kilda taking on Collingwood in what is tipped to be the game of the weekend.
At the moment, the Saints have the winning recipe and remain as one of the two teams that are undefeated.
Tim Membrey is in the frame for the Pies clash which could see either Anthony Caminiti or Zaine Cordy move to the side.
Tim Membrey is in line to play his first game of the season this week against Collingwood.@JoshGabelich has the details.https://t.co/Q1xdfEKpFJ
— AFL (@AFL) April 11, 2023
Craig McRae's ruck issues are unlikely to be fixed in the short-term, using Dan McStay, Ash Johnson and Billy Frampton.
This means Reef McInnes should count his lucky stars as his unlikely to be dropped.
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