Round 11 begins on Friday night with an intriguing clash between two struggling teams in Sydney and Carlton.
Super Saturday has many interesting contests with Naarm and Walyalup doing battle at the MCG, while Gold Coast hosts the Western Bulldogs at TIO Stadium.
Richmond will need to be ready for a hungry Port Adelaide outfit who have won seven on the trot while the weekend will be completed with Brisbane travelling to Adelaide Oval to take on the Crows.
MORE: Injury List: Geelong, Brisbane forced into changes as Eagles cop more woes
Sydney vs Carlton teams
Peter Ladhams was stretchered off last week but should be replaced by Tom Hickey, who needs to pass concussion protocols.
There's a host of VFL players pushing their case, but Sydney are coming off a comeback win against North Melbourne and will likely keep a similar line up.
After a disappointing outing against arch-rivals Collingwood last week, it wouldn't be a shock if Michael Voss decided to shift some magnets around.
George Hewett will likely come into the starting 22 to combat his former club's bullocking midfield brigade.
Tom De Koning's VFL efforts are worthy of a senior call up, which could come at the expense of Jack Silvangi.
Out-of-luck Paddy Dow continues to put his name in the ring as does untried youngster Jaxon Binns, yet they'd need to take the spot of Oliver Hollands, who was given the sub vest.
St Kilda vs Hawthorn teams
Mitch Owens will miss this week after a cruel clash with a teammate's knee, but will be replaced Tim Membrey if he passes concussion protocols.
Jack Bytel, Marcus Windhager and Jack Billins continue to put their hand up for a senior spot after strong form in the VFL.
St Kilda are unlikely to alter a winning combination and we all know Ross Lyon likes continuity.
After a 116-point thrashing of West Coast, Sam Mitchell wouldn't want to make too many changes.
Harry Morrison was managed for last week's game and could be brought in although it's hard to find someone who didn't play their role.
Jack Scrimshaw also put his hand up for selection after a strong outing in the twos.
Naarm (Melbourne) vs Walyalup (Fremantle) teams
Melbourne will be without Clayton Oliver (hamstring) and Lachie Hunter (suspension) for their clash with Walyalup (Fremantle).
Tom Sparrow returns from his suspension in an almost like-for-like with Oliver while James Jordon has previously filled a wing role.
James Harmes, Jake Melksham and Ben Brown are putting pressure on the senior forwards but haven't warranted a change of yet.
Hard to see Justin Longmuir making too many changes for this crucial clash against Naarm.
Nat Fyfe started in the 22 and was subbed as the club monitors his minutes as he returns from full health, with Matthew Johnson producing an impressive performance as the 23rd man.
Neil Erasmus could be brought in for Johnson, but unlikely.
Geelong vs GWS teams
Geelong will be without Max Holmes for at least a month but could see the return of Patrick Dangerfield, Gary Rohan and Sam De Koning.
All three will need to pass fitness tests if they are to play, which could see Oliver Dempsey and Sam Simpson face the axe.
Brandan Parfitt is another who has been in and out of the side in recent years while Mitch Knevitt replaced Rohan up forward.
The Giants will need to replace Josh Kelly (hamstring) as well as Nick Haynes and Harry Himmelberg through concussion.
Josh Fahey, Matt Flynn and Wade Dersken have put together strong reserves performances and are well within the mix to fill the void left by the injured trio.
Midfielders Harry Rowston and Callan Ward are also in the mix.
Gold Coast vs Western Bulldogs teams
Gold Coast will make one change, with Sean Lemmens injuring his hamstring.
Lachie Weller, Ben Long and Bodhi Uwland are options for Lemmens that Stuart Dew could use.
Sam Flanders and Mabior Chol produced impressive VFL performances and could put pressure on Sam Day (subbed) and Thomas Berry.
Luke Beveridge will need to make at least one change, with Jason Johannisen injuring his hamstring.
Adam Treloar is nearing a return and could be ready this week while Josh Bruce has been in waiting recently.
Hayden Crozier is the likely replacement for Johannisen across half back while the rest of the team will be safe after a dominant performance against Adelaide.
West Coast vs Essendon teams
Tom Barrass and Luke Edwards are likely to return from illness while Elliot Yeo and Shannon Hurn could be brought in if they are deemed available.
Rhett Bazzo struggled in defence and is a likely omission while a small host of players could be dropped after a smashing from Hawthorn.
If Edwards, Hurn and Yeo get up for this week, Greg Clark, Brady Hough and Noah Long are likely to make room.
Jamaine Jones is also a watch given he was subbed out with an ankle injury.
Essendon could welcome back Jayden Laverde, Dylan Shiel and Matt Guelfi to the starting line up.
After a hard-fought victory against Richmond, it will be hard to make changes although there are some vulnerable players.
Andrew Phillips, Massimo D'Ambrosio and Anthony McDonald-Tipungwuti could be the likely trio to make room for the Bombers this week.
Nick Bryan is also impressing in the VFL and could be in the mix for this weekend, while Kaine Baldwin replaced Laverde in the backline.
Richmond vs Yartapuulti (Port Adelaide) teams
Richmond will be full of emotion as Andrew McQualter replaces the recently resigned Damien Hardwick in the coaches box.
Nick Vlastuin suffered a corked leg in the loss to Essendon but is hopeful to get up.
As history suggests, the caretaker coach is unlikely to make unnecessary changes so don't expect too many new faces this week Tigers fans.
Tom Jonas has copped another suspension and will miss this week's clash against an emotionally charged Richmond, who recently saw the resignation of coach Damien Hardwick.
Tom Clurey is the likely replacement, while Todd Marshall (concussion) and Charlie Dixon (quad) remain there-abouts after dealing with their injuries.
If the two forwards get up, expect Ryan Burton to go down back to replace Jonas, while Ollie Lord could be the unlucky one for Dixon.
Collingwood vs North Melbourne teams
In a few weeks time, Craig McRae will need to make some tough decisions as some of their stars will put their hand up to return.
However, Sunday's clash with North Melbourne doesn't look like seeing too many changes.
Ash Johnson was subbed but not due to form, while Jack Ginnivan has impressed on limited minutes.
Expect no change.
Aidan Corr is available following his suspension while Flynn Perez (concussion), Cam Zurhaar (concussion) and Darcy Tucker (hamstring) should be ready to go on Sunday.
Liam Shiels (concussion) won't feature, Blake Drury's hip is sore and is no certainty to play.
Ben Cunnington was super in the reserves and could be brought in to offer some experience against a strong Collingwood midfield.
However, caretaker coach Brett Ratten will likely throw the responsibility to the youngsters.
Adelaide vs Brisbane teams
Adelaide will need to make at least one change given Mitch Hinge is out with concussion and will be replaced by Tom Doedee.
After missing Riley Thilthorpe and Taylor Walker last week, the forward pair are almost certain to return against Brisbane.
Elliot Himmelberg and Lachlan Gollant are the likely two who will be omitted given they came in for the Bulldogs game.
As for the Lions, Daniel Rich is locked to come back for Sunday's clash against the Crows.
Jack Payne will miss this week due to concussion while Keidean Coleman is in a race against the clock.
If Coleman comes out as well, expect Rich and either Darcy Gardiner or Darragh Joyce to fill his role.