Two interstate teams travel to Melbourne with their eye on establishing their premiership credentials.
West Coast will hit the Western Derby full of confidence, while North Melbourne are value in the battle of the cellar dwellers.
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Below are The Sporting News’ tips and predictions for Round 6:
Odds via TAB.
Collingwood vs. Port Adelaide prediction, tip, best bet
Collingwood are fresh off a bye but are yet to win at the MCG this season, losing to St Kilda and Sydney.
They weren't particularly impressive in their last outing at Gather Round against Hawthorn, holding on for dear life to win.
Port Adelaide already have a win at the MCG this season against Richmond and are value as the underdog in this contest.
The Power have only lost one game this season, arguably one they should have won at home against Melbourne.
Prediction: Port Adelaide by 12 points.
Best bet: Port Adelaide to win ($2.05)
Carlton vs. GWS prediction, tip, best bet
Injuries will affect both teams for this one but the missing players almost cancel each other out.
Carlton have lost Adam Saad, Adam Cerra and Mitch Govern, while the Giants will be absent Sam Taylor and Stephen Coniglio.
It certainly will be harder for the Giants to contain Charlie Curnow and Harry McKay without Taylor, but the Crows showed it is relatively possible with their young defence.
The Giants have the running power to expose Carlton.
Expect a shootout in this one.
Prediction: GWS by 7 points.
Best bet: GWS to win ($2.00)
West Coast vs. Fremantle prediction, tip, best bet
West Coast are long odds to win the derby despite an excellent win against Richmond last week.
There is no doubt that Fremantle should win this game, but the Dockers have shown they can struggle to score despite their stingy defence.
The Eagles' strongest part of their team is also their defence, with Jeremy McGovern and Tom Barrass looking fit at the moment.
All this points to a closer game than expected - which sees the value pick being West Coast at the line.
Prediction: Fremantle by 24 points.
Best bet: West Coast +33.5 ($1.90)
North Melbourne vs. Hawthorn prediction, tip, best bet
The AFL's two winless teams square off in the last match of the round on Sunday twilight.
While Hawthorn have performed better and been closer to a win, they have also been abysmal in several matches this season too.
There is no doubt the odds should be closer in this match, meaning North Melbourne at $3.00 is a juicy option, while the +16.5 line ($1.90) should also be considered.
Prediction: North Melbourne by 4 points.
Best bet: North Melbourne to win ($3.00)
